HCSGD entry for TMPRSS2
1. General information
| Official gene symbol | TMPRSS2 |
|---|---|
| Entrez ID | 7113 |
| Gene full name | transmembrane protease, serine 2 |
| Other gene symbols | PP9284 PRSS10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005044 | Scavenger receptor activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008236 | Serine-type peptidase activity | TAS | molecular_function |
| GO:0016020 | Membrane | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3106888074 | 0.7789807986 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0725400662 |
| GSE13712_SHEAR | Down | -0.0413284076 |
| GSE13712_STATIC | Up | 0.0326924584 |
| GSE19018 | Up | 0.0105459761 |
| GSE19899_A1 | Up | 0.0951254512 |
| GSE19899_A2 | Up | 0.0837910964 |
| PubMed_21979375_A1 | Down | -0.0274740590 |
| PubMed_21979375_A2 | Up | 0.0210652932 |
| GSE35957 | Up | 0.1142561554 |
| GSE36640 | Up | 0.1076801640 |
| GSE54402 | Down | -0.0283019113 |
| GSE9593 | Up | 0.1157462197 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.0546299610 |
| GSE28863_A2 | Down | -0.4217244736 |
| GSE28863_A3 | Up | 0.8107091484 |
| GSE28863_A4 | Up | 0.0992932009 |
| GSE48662 | Up | 0.2479374548 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23272087 | Notably, knockdown of the ATM gene expression in HPr-1AR cells can promote androgen-induced TMPRSS2: ERG rearrangement, a prostate-specific chromosome translocation frequently found in prostate cancer cells |
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