HCSGD entry for NR2E1

1. General information

Official gene symbolNR2E1
Entrez ID7101
Gene full namenuclear receptor subfamily 2, group E, member 1
Other gene symbolsTLL TLX XTLL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIEAmolecular_function
GO:0001662Behavioral fear responseIEAbiological_process
GO:0002118Aggressive behaviorIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007601Visual perceptionIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008347Glial cell migrationIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0021542Dentate gyrus developmentIEAbiological_process
GO:0021764Amygdala developmentIEAbiological_process
GO:0021772Olfactory bulb developmentIEAbiological_process
GO:0021819Layer formation in cerebral cortexIEAbiological_process
GO:0021872Forebrain generation of neuronsIEAbiological_process
GO:0021895Cerebral cortex neuron differentiationIEAbiological_process
GO:0021960Anterior commissure morphogenesisIEAbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0035176Social behaviorIEAbiological_process
GO:0042826Histone deacetylase bindingIEAmolecular_function
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045165Cell fate commitmentIEAbiological_process
GO:0045665Negative regulation of neuron differentiationIEAbiological_process
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0045787Positive regulation of cell cycleIEAbiological_process
GO:0048712Negative regulation of astrocyte differentiationIEAbiological_process
GO:0048814Regulation of dendrite morphogenesisIEAbiological_process
GO:0060041Retina development in camera-type eyeIEAbiological_process
GO:0060164Regulation of timing of neuron differentiationIEAbiological_process
GO:0060291Long-term synaptic potentiationIEAbiological_process
GO:0090049Regulation of cell migration involved in sprouting angiogenesisIEAbiological_process
GO:2000178Negative regulation of neural precursor cell proliferationIEAbiological_process
GO:2000179Positive regulation of neural precursor cell proliferationIEAbiological_process
GO:2000648Positive regulation of stem cell proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.35147680940.91937721210.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0151216074
GSE13712_SHEARDown-0.2256315079
GSE13712_STATICDown-0.0579390732
GSE19018Up0.0757527334
GSE19899_A1Up0.1400204991
GSE19899_A2Down-0.0166781934
PubMed_21979375_A1Up0.0935534728
PubMed_21979375_A2Up0.0366919792
GSE35957Down-0.1592308417
GSE36640Up0.1042031918
GSE54402Down-0.0101524274
GSE9593Up0.1192352372
GSE43922Up0.0310049484
GSE24585Up0.3739038718
GSE37065Up0.0256551964
GSE28863_A1Down-0.0099374747
GSE28863_A2Up0.0894912992
GSE28863_A3Up0.3425193813
GSE28863_A4Up0.2399428602
GSE48662Down-0.0260330336

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT004618immunoblot//Luciferase reporter assay//Northern blot//Western blotFunctional MTI20133835
hsa-miR-9-5pMIMAT0000441MIRT004982GFP reporter assay//Immunocytochemistry//Immunoprecipitaion//Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI19330006
hsa-miR-26b-5pMIMAT0000083MIRT029877MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25328137The nuclear receptor NR2E1/TLX controls senescence
25328137Despite NR2E1 regulating targets like p21(CIP1) or PTEN we still lack a full explanation for its role in NSC self-renewal and tumorigenesis
25328137We know that polycomb repressive complexes also control stem cell self-renewal and tumorigenesis, but so far, no formal connection has been established between NR2E1 and PRCs
25328137In a screen for transcription factors regulating the expression of the polycomb protein CBX7, we identified NR2E1 as one of its more prominent regulators
25328137NR2E1 binds at the CBX7 promoter, inducing its expression
25328137Notably CBX7 represses NR2E1 as part of a regulatory loop
25328137Ectopic NR2E1 expression inhibits cellular senescence, extending cellular lifespan in fibroblasts via CBX7-mediated regulation of p16(INK4a) and direct repression of p21(CIP1)
25328137In addition NR2E1 expression also counteracts oncogene-induced senescence
25328137The importance of NR2E1 to restrain senescence is highlighted through the process of knocking down its expression, which causes premature senescence in human fibroblasts and epithelial cells
25328137We also confirmed that NR2E1 regulates CBX7 and restrains senescence in NSCs
25328137Finally, we observed that the expression of NR2E1 directly correlates with that of CBX7 in human glioblastoma multiforme
25328137Overall we identified control of senescence and regulation of polycomb action as two possible mechanisms that can join those so far invoked to explain the role of NR2E1 in control of NSC self-renewal and cancer
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