HCSGD entry for SERPING1

1. General information

Official gene symbolSERPING1
Entrez ID710
Gene full nameserpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Other gene symbolsC1IN C1INH C1NH HAE1 HAE2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001869Negative regulation of complement activation, lectin pathwayIDAbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0004867Serine-type endopeptidase inhibitor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceIBA IEAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006958Complement activation, classical pathwayIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007597Blood coagulation, intrinsic pathwayTASbiological_process
GO:0008015Blood circulationTASbiological_process
GO:0008233Peptidase activityIEAmolecular_function
GO:0010951Negative regulation of endopeptidase activityIBAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030193Regulation of blood coagulationIEAbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0042730FibrinolysisIEAbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0045916Negative regulation of complement activationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00894342160.13761854790.24220020580.7145902150

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6746516066
GSE13712_SHEARUp0.2666969311
GSE13712_STATICDown-0.0819777301
GSE19018Up1.3006692477
GSE19899_A1Down-0.3602773512
GSE19899_A2Down-0.4833262286
PubMed_21979375_A1Up0.0410536479
PubMed_21979375_A2Down-0.3687771913
GSE35957Up0.2934620594
GSE36640Up0.7136785804
GSE54402Down-1.0058883671
GSE9593Down-0.1199927681
GSE43922Down-0.1393728429
GSE24585Up0.6450794065
GSE37065Up0.3401883710
GSE28863_A1Up0.7806495424
GSE28863_A2Up0.8851235284
GSE28863_A3Up0.9861115760
GSE28863_A4Down-0.2552395803
GSE48662Up0.6605603943

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

C1-INHDB05341 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018847MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.