HCSGD entry for TLR4

1. General information

Official gene symbolTLR4
Entrez ID7099
Gene full nametoll-like receptor 4
Other gene symbolsARMD10 CD284 TLR-4 TOLL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityISSbiological_process
GO:0001530Lipopolysaccharide bindingIMP NASmolecular_function
GO:0001875Lipopolysaccharide receptor activityIDAmolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002322B cell proliferation involved in immune responseIEAbiological_process
GO:0002537Nitric oxide production involved in inflammatory responseIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0004888Transmembrane signaling receptor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006955Immune responseTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0007252I-kappaB phosphorylationIDAbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0010008Endosome membraneTAScellular_component
GO:0010572Positive regulation of platelet activationISSbiological_process
GO:0016046Detection of fungusNASbiological_process
GO:0030890Positive regulation of B cell proliferationIEAbiological_process
GO:0031663Lipopolysaccharide-mediated signaling pathwayIDA IGIbiological_process
GO:0032496Response to lipopolysaccharideIC IDAbiological_process
GO:0032497Detection of lipopolysaccharideIDAbiological_process
GO:0032609Interferon-gamma productionIEAbiological_process
GO:0032689Negative regulation of interferon-gamma productionISSbiological_process
GO:0032700Negative regulation of interleukin-17 productionISSbiological_process
GO:0032707Negative regulation of interleukin-23 productionISSbiological_process
GO:0032715Negative regulation of interleukin-6 productionISSbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionISSbiological_process
GO:0032722Positive regulation of chemokine productionIDAbiological_process
GO:0032727Positive regulation of interferon-alpha productionISSbiological_process
GO:0032728Positive regulation of interferon-beta productionISSbiological_process
GO:0032729Positive regulation of interferon-gamma productionISSbiological_process
GO:0032732Positive regulation of interleukin-1 productionISSbiological_process
GO:0032733Positive regulation of interleukin-10 productionISSbiological_process
GO:0032735Positive regulation of interleukin-12 productionISSbiological_process
GO:0032755Positive regulation of interleukin-6 productionIDAbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionISSbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042088T-helper 1 type immune responseNASbiological_process
GO:0042116Macrophage activationIMPbiological_process
GO:0042346Positive regulation of NF-kappaB import into nucleusIDAbiological_process
GO:0042535Positive regulation of tumor necrosis factor biosynthetic processIDAbiological_process
GO:0042742Defense response to bacteriumTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEAbiological_process
GO:0045084Positive regulation of interleukin-12 biosynthetic processIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045348Positive regulation of MHC class II biosynthetic processIEAbiological_process
GO:0045359Positive regulation of interferon-beta biosynthetic processIEAbiological_process
GO:0045416Positive regulation of interleukin-8 biosynthetic processIDAbiological_process
GO:0045429Positive regulation of nitric oxide biosynthetic processIEAbiological_process
GO:0045671Negative regulation of osteoclast differentiationNASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046330Positive regulation of JNK cascadeIEAbiological_process
GO:0046696Lipopolysaccharide receptor complexIDAcellular_component
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050707Regulation of cytokine secretionIEAbiological_process
GO:0050729Positive regulation of inflammatory responseICbiological_process
GO:0050829Defense response to Gram-negative bacteriumICbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051770Positive regulation of nitric-oxide synthase biosynthetic processISSbiological_process
GO:0060729Intestinal epithelial structure maintenanceISSbiological_process
GO:0060907Positive regulation of macrophage cytokine productionIEAbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0070430Positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathwayIEAbiological_process
GO:0070434Positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathwayIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideISSbiological_process
GO:0071223Cellular response to lipoteichoic acidIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03703475170.89817764900.43640155141.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1728513166
GSE13712_SHEARUp0.4766557924
GSE13712_STATICUp0.3861442930
GSE19018Up0.0528600755
GSE19899_A1Up0.0726574135
GSE19899_A2Up0.1223156806
PubMed_21979375_A1Up0.2265635353
PubMed_21979375_A2Up0.0865769736
GSE35957Up0.2555558966
GSE36640Up0.2538519518
GSE54402Up0.0062981312
GSE9593Up0.7517681828
GSE43922Up0.2267134945
GSE24585Up0.1369811226
GSE37065Up0.4362727935
GSE28863_A1Up0.0108192829
GSE28863_A2Up0.3024029238
GSE28863_A3Down-1.0014186922
GSE28863_A4Up0.2018625338
GSE48662Up0.1051021997

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL224199CHEMBL52559O00206
CHEMBL224563CHEMBL52559O00206
CHEMBL426184CHEMBL52559O00206
CHEMBL375048CHEMBL52559O00206
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  • Drugs

Name

Drug

Accession number

NaloxoneDB01183 APRD00025
3-Hydroxy-Myristic AcidDB02767 EXPT01506
EritoranDB04933 -
SCV-07DB05475 -
MYRISTIC ACIDDB08231 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7i-5pMIMAT0000415MIRT003050Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI17660297
hsa-miR-146a-5pMIMAT0000449MIRT006530ELISA//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI21329689
hsa-miR-335-5pMIMAT0000765MIRT018411MicroarrayFunctional MTI (Weak)18185580
hsa-miR-1MIMAT0000416MIRT023907MicroarrayFunctional MTI (Weak)18668037
hsa-miR-21-5pMIMAT0000076MIRT031004MicroarrayFunctional MTI (Weak)18591254
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-let-7i-5pMIMAT00004151hsa-let-7i{Western blot}{Western blot}{underexpression by 2'-O-Me antisense miRNA oligonucleotides}{overexpression by miRNA precursor transfection}17660297
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25500818They are involved in cell phenotype switching, response to shear stress, cell senescence, adhesion molecule expression, macrophage response to oxidised low-density lipoprotein, Toll-like receptor 4 expression, neointimal lesion formation, plaque angiogenesis and cellular cholesterol homeostasis
24917789In contrast, 16 DIV (aged) microglia evidenced ramified morphology and increased matrix metalloproteinase (MMP)-2 activation, as well as reduced MMP-9, glutamate release and nuclear factor kappa-B activation, in parallel with decreased expression of Toll-like receptor (TLR)-2 and TLR-4, capacity to migrate and phagocytose
24676500We found that the LPS bound with Toll-like receptor 4 (TLR4) and that TLR4 signaling accounted for p16(INK4A) expression
23649808Senescent fibroblasts secreted oxidized HMGB1, which stimulated cytokine secretion through TLR-4 signaling
23649808HMGB1 depletion, HMGB1 blocking antibody, or TLR-4 inhibition attenuated senescence-associated IL-6 secretion, and exogenous HMGB1 stimulated NF-kappaB activity and restored IL-6 secretion to HMGB1-depleted cells
23299825Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice
23299825Suppressed immune networks resulted in a halt of cellular senescence induction in TLR4 mutant liver tissue, which promoted proliferation and suppressed programmed cell death
23299825Moreover, TLR4 mutation resulted in a suppressed capacity of DNA repair due to a decrease in TLR4-medicated expression of DNA repair proteins Ku70/80 in liver tissue and cells
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