HCSGD entry for TLE4
1. General information
| Official gene symbol | TLE4 |
|---|---|
| Entrez ID | 7091 |
| Gene full name | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) |
| Other gene symbols | BCE-1 BCE1 E(spI) ESG ESG4 GRG4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA NAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0070491 | Repressing transcription factor binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5694235781 | 0.0136183960 | 0.9999902473 | 0.2299335253 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1226339840 |
| GSE13712_SHEAR | Up | 0.4375369523 |
| GSE13712_STATIC | Down | -0.1777234893 |
| GSE19018 | Up | 0.4889286582 |
| GSE19899_A1 | Down | -0.2011021501 |
| GSE19899_A2 | Down | -0.9001134671 |
| PubMed_21979375_A1 | Down | -1.7330718377 |
| PubMed_21979375_A2 | Down | -0.9395930920 |
| GSE35957 | Up | 0.0787164073 |
| GSE36640 | Up | 0.2290691347 |
| GSE54402 | Down | -0.6390642136 |
| GSE9593 | Up | 0.5317570117 |
| GSE43922 | Down | -1.3605005123 |
| GSE24585 | Up | 0.2158266820 |
| GSE37065 | Up | 0.1392756671 |
| GSE28863_A1 | Up | 0.3155816567 |
| GSE28863_A2 | Down | -0.5348769262 |
| GSE28863_A3 | Down | -1.0096547498 |
| GSE28863_A4 | Up | 0.0348334777 |
| GSE48662 | Down | -0.0147778210 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT005105 | Microarray | Functional MTI (Weak) | 19193853 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT005105 | Reporter assay;Other | Functional MTI | 20584899 |
| hsa-miR-548b-3p | MIMAT0003254 | MIRT016236 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017745 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021114 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027063 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029323 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031643 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032123 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041429 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046892 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
