HCSGD entry for TKT
1. General information
| Official gene symbol | TKT |
|---|---|
| Entrez ID | 7086 |
| Gene full name | transketolase |
| Other gene symbols | TK TKT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004802 | Transketolase activity | EXP IDA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005777 | Peroxisome | ISS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0005999 | Xylulose biosynthetic process | TAS | biological_process |
| GO:0006098 | Pentose-phosphate shunt | TAS | biological_process |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0009052 | Pentose-phosphate shunt, non-oxidative branch | NAS | biological_process |
| GO:0040008 | Regulation of growth | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046166 | Glyceraldehyde-3-phosphate biosynthetic process | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048037 | Cofactor binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8584209453 | 0.0338875119 | 0.9999902473 | 0.3473277929 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0986183749 |
| GSE13712_SHEAR | Down | -0.4495585995 |
| GSE13712_STATIC | Down | -0.0098349230 |
| GSE19018 | Down | -0.1390331964 |
| GSE19899_A1 | Down | -0.3935554902 |
| GSE19899_A2 | Down | -0.2373196967 |
| PubMed_21979375_A1 | Down | -0.1146398587 |
| PubMed_21979375_A2 | Down | -0.2201792951 |
| GSE35957 | Down | -0.6819843049 |
| GSE36640 | Down | -0.4094981055 |
| GSE54402 | Up | 0.2675044370 |
| GSE9593 | Down | -0.2479611205 |
| GSE43922 | Down | -0.0158025092 |
| GSE24585 | Down | -0.8252850945 |
| GSE37065 | Down | -0.2948380741 |
| GSE28863_A1 | Up | 0.9397603096 |
| GSE28863_A2 | Up | 0.3066160208 |
| GSE28863_A3 | Down | -0.2924873007 |
| GSE28863_A4 | Down | -0.1030871906 |
| GSE48662 | Down | -0.0668051856 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT024031 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038566 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041785 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043397 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045530 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047913 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049252 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050103 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
