HCSGD entry for TIE1

1. General information

Official gene symbolTIE1
Entrez ID7075
Gene full nametyrosine kinase with immunoglobulin-like and EGF-like domains 1
Other gene symbolsJTK14 TIE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001570VasculogenesisIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneIEAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007498Mesoderm developmentTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016525Negative regulation of angiogenesisIEAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0030336Negative regulation of cell migrationIEAbiological_process
GO:0032526Response to retinoic acidIEAbiological_process
GO:0045026Plasma membrane fusionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03536689720.95376740250.42866542361.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0463060827
GSE13712_SHEARDown-0.1052681112
GSE13712_STATICDown-0.3731415865
GSE19018Up0.2560083936
GSE19899_A1Up0.1445936633
GSE19899_A2Up0.3851985665
PubMed_21979375_A1Up1.1297052840
PubMed_21979375_A2Up0.1634015547
GSE35957Down-0.0675991013
GSE36640Down-0.1610437061
GSE54402Up2.4742345901
GSE9593Up0.1728117905
GSE43922Up0.8589045377
GSE24585Up0.0213478739
GSE37065Up0.0034912235
GSE28863_A1Down-0.0869508224
GSE28863_A2Up0.0422976466
GSE28863_A3Up0.1477081224
GSE28863_A4Up0.1371682515
GSE48662Up0.0816622571

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.