HCSGD entry for TIA1
1. General information
| Official gene symbol | TIA1 |
|---|---|
| Entrez ID | 7072 |
| Gene full name | TIA1 cytotoxic granule-associated RNA binding protein |
| Other gene symbols | TIA-1 WDM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0008143 | Poly(A) binding | TAS | molecular_function |
| GO:0010494 | Cytoplasmic stress granule | IDA IEA | cellular_component |
| GO:0017091 | AU-rich element binding | IEA | molecular_function |
| GO:0017148 | Negative regulation of translation | IEA | biological_process |
| GO:0042036 | Negative regulation of cytokine biosynthetic process | IEA | biological_process |
| GO:0048024 | Regulation of mRNA splicing, via spliceosome | IDA | biological_process |
| GO:0097165 | Nuclear stress granule | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9913282740 | 0.0045446450 | 0.9999902473 | 0.1363018223 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0350774817 |
| GSE13712_SHEAR | Down | -0.1596954414 |
| GSE13712_STATIC | Down | -0.1697597892 |
| GSE19018 | Down | -0.2206429695 |
| GSE19899_A1 | Down | -0.5214050290 |
| GSE19899_A2 | Down | -0.9144549438 |
| PubMed_21979375_A1 | Down | -0.9630236732 |
| PubMed_21979375_A2 | Down | -0.9619254512 |
| GSE35957 | Down | -0.7448757426 |
| GSE36640 | Down | -0.4921946163 |
| GSE54402 | Down | -0.1935100729 |
| GSE9593 | Down | -1.0323137478 |
| GSE43922 | Down | -0.4105299045 |
| GSE24585 | Down | -0.0545045491 |
| GSE37065 | Up | 0.1051499947 |
| GSE28863_A1 | Up | 0.2729345219 |
| GSE28863_A2 | Up | 0.3316871691 |
| GSE28863_A3 | Down | -0.9284663333 |
| GSE28863_A4 | Down | -0.3403761274 |
| GSE48662 | Down | -0.1847202695 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT000909 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000910 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028191 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029253 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036261 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043294 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | NA | hsa-miR-15a | 18362358 | |||
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | 18362358 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
