HCSGD entry for KLF10
1. General information
| Official gene symbol | KLF10 |
|---|---|
| Entrez ID | 7071 |
| Gene full name | Kruppel-like factor 10 |
| Other gene symbols | EGRA TIEG TIEG1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0030282 | Bone mineralization | IEA | biological_process |
| GO:0035019 | Somatic stem cell maintenance | IEA | biological_process |
| GO:0045672 | Positive regulation of osteoclast differentiation | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:1901653 | Cellular response to peptide | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0266048098 | 0.8175949736 | 0.3803090466 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7212736770 |
| GSE13712_SHEAR | Up | 0.4740885940 |
| GSE13712_STATIC | Up | 0.9170135264 |
| GSE19018 | Down | -0.6492917458 |
| GSE19899_A1 | Up | 1.1390739941 |
| GSE19899_A2 | Up | 0.0954373311 |
| PubMed_21979375_A1 | Up | 1.1267280245 |
| PubMed_21979375_A2 | Up | 0.4409404231 |
| GSE35957 | Down | -0.1209538222 |
| GSE36640 | Up | 0.0363966719 |
| GSE54402 | Down | -0.1343280024 |
| GSE9593 | Up | 0.1180322549 |
| GSE43922 | Up | 0.0703497242 |
| GSE24585 | Up | 0.5186244387 |
| GSE37065 | Up | 0.1345302868 |
| GSE28863_A1 | Up | 0.0972679462 |
| GSE28863_A2 | Up | 0.2768783830 |
| GSE28863_A3 | Up | 0.3233718212 |
| GSE28863_A4 | Up | 0.0086331164 |
| GSE48662 | Down | -0.1615471300 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-197-3p | MIMAT0000227 | MIRT004212 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019621 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT023455 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024713 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026652 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027610 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031303 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043862 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
