HCSGD entry for THOP1
1. General information
| Official gene symbol | THOP1 |
|---|---|
| Entrez ID | 7064 |
| Gene full name | thimet oligopeptidase 1 |
| Other gene symbols | EP24.15 MEPD_HUMAN MP78 TOP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006518 | Peptide metabolic process | IEA | biological_process |
| GO:0042277 | Peptide binding | IEA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1722693743 | 0.4165511493 | 0.8151346624 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0674442311 |
| GSE13712_SHEAR | Up | 0.2116484911 |
| GSE13712_STATIC | Up | 0.1565123300 |
| GSE19018 | Up | 0.1330821488 |
| GSE19899_A1 | Up | 0.2118393838 |
| GSE19899_A2 | Up | 0.1501652738 |
| PubMed_21979375_A1 | Up | 0.1088795657 |
| PubMed_21979375_A2 | Up | 0.7659806685 |
| GSE35957 | Down | -0.5795139316 |
| GSE36640 | Down | -0.0903313277 |
| GSE54402 | Up | 0.2789815527 |
| GSE9593 | Down | -0.0879926747 |
| GSE43922 | Up | 0.0523855213 |
| GSE24585 | Down | -0.3984174037 |
| GSE37065 | Down | -0.3126949362 |
| GSE28863_A1 | Down | -0.2432620672 |
| GSE28863_A2 | Down | -0.3043566344 |
| GSE28863_A3 | Up | 0.4581818706 |
| GSE28863_A4 | Up | 0.2309998543 |
| GSE48662 | Down | -0.0236292307 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020122 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024285 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026106 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030367 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031093 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-935 | MIMAT0004978 | MIRT036680 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-425-5p | MIMAT0003393 | MIRT039328 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040074 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041034 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041826 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046579 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
