HCSGD entry for TSPO

1. General information

Official gene symbolTSPO
Entrez ID706
Gene full nametranslocator protein (18kDa)
Other gene symbolsBPBS BZRP DBI IBP MBR PBR PBS PKBS PTBR mDRC pk18
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005497Androgen bindingIEAmolecular_function
GO:0005741Mitochondrial outer membraneIEAcellular_component
GO:0006626Protein targeting to mitochondrionTASbiological_process
GO:0006694Steroid biosynthetic processIEAbiological_process
GO:0006783Heme biosynthetic processTASbiological_process
GO:0006820Anion transportTASbiological_process
GO:0006821Chloride transportIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0008347Glial cell migrationIEAbiological_process
GO:0008503Benzodiazepine receptor activityIEAmolecular_function
GO:0010042Response to manganese ionIEAbiological_process
GO:0010266Response to vitamin B1IEAbiological_process
GO:0010940Positive regulation of necrotic cell deathIEAbiological_process
GO:0014012Peripheral nervous system axon regenerationIEAbiological_process
GO:0015485Cholesterol bindingTASmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0030325Adrenal gland developmentIEAbiological_process
GO:0032374Regulation of cholesterol transportTASbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIEAbiological_process
GO:0033574Response to testosteroneIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0045019Negative regulation of nitric oxide biosynthetic processIEAbiological_process
GO:0048266Behavioral response to painIEAbiological_process
GO:0050810Regulation of steroid biosynthetic processIEAbiological_process
GO:0051901Positive regulation of mitochondrial depolarizationIEAbiological_process
GO:0051928Positive regulation of calcium ion transportIEAbiological_process
GO:0060242Contact inhibitionIEAbiological_process
GO:0060252Positive regulation of glial cell proliferationIEAbiological_process
GO:0060253Negative regulation of glial cell proliferationIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071294Cellular response to zinc ionIEAbiological_process
GO:0071476Cellular hypotonic responseIEAbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06873801530.59262289050.56237099971.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2593565278
GSE13712_SHEARUp0.0092480421
GSE13712_STATICUp0.0354602090
GSE19018Up0.6487057228
GSE19899_A1Up0.0380567596
GSE19899_A2Up0.6099079689
PubMed_21979375_A1Up2.2770954417
PubMed_21979375_A2Up0.2014488696
GSE35957Down-0.2009976177
GSE36640Up0.9128513940
GSE54402Up0.1737675609
GSE9593Up0.2401467034
GSE43922Up0.0378030711
GSE24585Down-0.2158596884
GSE37065Down-0.2992871664
GSE28863_A1Down-0.1373791583
GSE28863_A2Down-0.4472680282
GSE28863_A3Down-0.5256781214
GSE28863_A4Up0.0850568159
GSE48662Down-0.2243379354

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

LorazepamDB00186 APRD00116
TemazepamDB00231 APRD00676
ClorazepateDB00628 APRD00881
DiazepamDB00829 APRD00642 | DB07699
TriazolamDB00897 APRD00313
ZaleplonDB00962 APRD00411
ZopicloneDB01198 APRD00356
FlunitrazepamDB01544 -
KetazolamDB01587 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25700847A number of cellular changes have been identified in the steroidogenic pathway of aged Leydig cells that are associated with reduced T formation, including reductions in luteinizing hormone (LH)-stimulated cAMP production, the cholesterol transport proteins steroidogenic acute regulatory (STAR) protein and translocator protein (TSPO), and downstream steroidogenic enzymes of the mitochondria and smooth endoplasmic reticulum
15611563Previous studies have shown that the capacity of Leydig cells from aged (21-24-month-old) Brown Norway rats to produce testosterone is reduced from young (4-month-old) levels, and that this is correlated with reductions in steroidogenic acute regulatory protein (StAR), peripheral benzodiazapine receptor (PBR), and the levels and activities of the steroidogenic enzymes
8688440In the first case an exclusive role is supposed to play the mitochondrial benzodiazepine receptor and components, regulating the activity of its participants (mitochondrial porin and adenine nucleotide translocator)
8688440The possible transport of nucleic acids through Ca(2+)-dependent permeability transition pore, representing one of the functional states of mitochondrial benzodiazepine receptor, is put forth
9035744In the latter case, important roles for mitochondrial benzodiazepine receptor and factors that regulate activities of its components (mitochondrial porin and adenine nucleotide translocator) are suggested
9035744Problems like cellular aging, apoptosis, proliferation, mitochondrial diseases, multidrug resistance, intracellular traffic, and mitochondrial heredity are discussed considering an important role of mitochondrial benzodiazepine receptor in these processes
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