HCSGD entry for THBS1

1. General information

Official gene symbolTHBS1
Entrez ID7057
Gene full namethrombospondin 1
Other gene symbolsTHBS THBS-1 TSP TSP-1 TSP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIMPbiological_process
GO:0001666Response to hypoxiaNASbiological_process
GO:0001786Phosphatidylserine bindingIDAmolecular_function
GO:0001937Negative regulation of endothelial cell proliferationIDA IMPbiological_process
GO:0001948Glycoprotein bindingNASmolecular_function
GO:0001953Negative regulation of cell-matrix adhesionIDAbiological_process
GO:0001968Fibronectin bindingIDAmolecular_function
GO:0002040Sprouting angiogenesisIMPbiological_process
GO:0002544Chronic inflammatory responseIEPbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0002581Negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIIDAbiological_process
GO:0002605Negative regulation of dendritic cell antigen processing and presentationIDAbiological_process
GO:0003151Outflow tract morphogenesisIEAbiological_process
GO:0003197Endocardial cushion developmentIEAbiological_process
GO:0003417Growth plate cartilage developmentIEAbiological_process
GO:0005178Integrin bindingIMPmolecular_function
GO:0005509Calcium ion bindingNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005577Fibrinogen complexIDAcellular_component
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005783Endoplasmic reticulumISScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseIEPbiological_process
GO:0006986Response to unfolded proteinIEAbiological_process
GO:0007050Cell cycle arrestIDAbiological_process
GO:0007155Cell adhesionNASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008201Heparin bindingIDA IEAmolecular_function
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009749Response to glucoseIDAbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0009986Cell surfaceIDAcellular_component
GO:0010595Positive regulation of endothelial cell migrationIDAbiological_process
GO:0010596Negative regulation of endothelial cell migrationIDAbiological_process
GO:0010748Negative regulation of plasma membrane long-chain fatty acid transportIDAbiological_process
GO:0010751Negative regulation of nitric oxide mediated signal transductionIDAbiological_process
GO:0010754Negative regulation of cGMP-mediated signalingIDAbiological_process
GO:0010757Negative regulation of plasminogen activationIDAbiological_process
GO:0010759Positive regulation of macrophage chemotaxisISSbiological_process
GO:0010763Positive regulation of fibroblast migrationIDAbiological_process
GO:0010811Positive regulation of cell-substrate adhesionIEAbiological_process
GO:0016477Cell migrationIDAbiological_process
GO:0016525Negative regulation of angiogenesisIDA IEAbiological_process
GO:0016529Sarcoplasmic reticulumISScellular_component
GO:0017134Fibroblast growth factor bindingIDAmolecular_function
GO:0018149Peptide cross-linkingIDAbiological_process
GO:0030141Secretory granuleIDAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0030169Low-density lipoprotein particle bindingIDAmolecular_function
GO:0030194Positive regulation of blood coagulationIDAbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030335Positive regulation of cell migrationIDA IMPbiological_process
GO:0030511Positive regulation of transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0031012Extracellular matrixIDA ISS TAScellular_component
GO:0031091Platelet alpha granuleIDAcellular_component
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0032026Response to magnesium ionIDAbiological_process
GO:0032570Response to progesteroneTASbiological_process
GO:0032695Negative regulation of interleukin-12 productionIDAbiological_process
GO:0032914Positive regulation of transforming growth factor beta1 productionISSbiological_process
GO:0033574Response to testosteroneIEAbiological_process
GO:0034605Cellular response to heatNASbiological_process
GO:0034976Response to endoplasmic reticulum stressISSbiological_process
GO:0040037Negative regulation of fibroblast growth factor receptor signaling pathwayIDAbiological_process
GO:0042327Positive regulation of phosphorylationIMPbiological_process
GO:0042493Response to drugIEPbiological_process
GO:0042535Positive regulation of tumor necrosis factor biosynthetic processIDAbiological_process
GO:0042802Identical protein bindingNASmolecular_function
GO:0043032Positive regulation of macrophage activationIDAbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043236Laminin bindingIDAmolecular_function
GO:0043394Proteoglycan bindingTASmolecular_function
GO:0043536Positive regulation of blood vessel endothelial cell migrationIDAbiological_process
GO:0043537Negative regulation of blood vessel endothelial cell migrationIDAbiological_process
GO:0043652Engulfment of apoptotic cellIDAbiological_process
GO:0045727Positive regulation of translationIDAbiological_process
GO:0045766Positive regulation of angiogenesisIMPbiological_process
GO:0048266Behavioral response to painISSbiological_process
GO:0048514Blood vessel morphogenesisIEAbiological_process
GO:0050431Transforming growth factor beta bindingIEA ISS TASmolecular_function
GO:0050840Extracellular matrix bindingIEAmolecular_function
GO:0050921Positive regulation of chemotaxisIDAbiological_process
GO:0051592Response to calcium ionIDAbiological_process
GO:0051895Negative regulation of focal adhesion assemblyTASbiological_process
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0051918Negative regulation of fibrinolysisIDAbiological_process
GO:0070051Fibrinogen bindingIDAmolecular_function
GO:0070052Collagen V bindingIDAmolecular_function
GO:0070062Extracellular vesicular exosomeIDAcellular_component
GO:0071356Cellular response to tumor necrosis factorIEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0071636Positive regulation of transforming growth factor beta productionIEAbiological_process
GO:1902043Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIDAbiological_process
GO:2000353Positive regulation of endothelial cell apoptotic processIDAbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processIDAbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.21543694010.00292313360.89352618560.1079099579

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1493195500
GSE13712_SHEARDown-0.1682815007
GSE13712_STATICDown-0.1877271631
GSE19018Up0.1839014799
GSE19899_A1Down-1.4153587196
GSE19899_A2Down-0.8757032960
PubMed_21979375_A1Down-2.6834516578
PubMed_21979375_A2Down-2.0811362346
GSE35957Up1.0208933934
GSE36640Up0.8715861087
GSE54402Down-1.6340122238
GSE9593Down-0.3560136313
GSE43922Down-0.6912921166
GSE24585Up1.3144796286
GSE37065Down-1.1502246164
GSE28863_A1Down-0.2354962334
GSE28863_A2Up0.0629123403
GSE28863_A3Up0.1995928818
GSE28863_A4Down-0.2444993807
GSE48662Up0.5818683380

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT001328pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-let-7b-5pMIMAT0000063MIRT001586pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-30a-3pMIMAT0000088MIRT001763Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI16239240
hsa-miR-98-5pMIMAT0000096MIRT004943qRT-PCRFunctional MTI (Weak)17942906
hsa-miR-98-5pMIMAT0000096MIRT004943MicroarrayFunctional MTI (Weak)19088304
hsa-let-7a-5pMIMAT0000062MIRT004958qRT-PCRFunctional MTI (Weak)17942906
hsa-miR-17-5pMIMAT0000070MIRT005626Microarray//qRT-PCRNon-Functional MTI (Weak)20940405
hsa-miR-20a-5pMIMAT0000075MIRT005627Microarray//qRT-PCRNon-Functional MTI (Weak)20940405
hsa-miR-92a-3pMIMAT0000092MIRT005628Microarray//qRT-PCRNon-Functional MTI (Weak)20940405
hsa-miR-155-5pMIMAT0000646MIRT020932ProteomicsFunctional MTI (Weak)18668040
hsa-miR-132-3pMIMAT0000426MIRT021834MicroarrayFunctional MTI (Weak)17612493
hsa-miR-30a-5pMIMAT0000087MIRT028645ProteomicsFunctional MTI (Weak)18668040
hsa-let-7d-5pMIMAT0000065MIRT032122SequencingFunctional MTI (Weak)20371350
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-19a-3pMIMAT0000073NAhsa-miR-19a{Western blot}{overexpression by miRNA precursor transfection}20299512
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23871936Significantly, TSP-1 itself was unable to induce senescence phenotype in HPMCs or in HPFBs
23119050Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process
23119050We aimed to analyse the role of p38-MAPK and HIF-1 in the transcriptional regulation of CD36, a class B scavenger receptor, and its ligand thrombospondin (TSP-1) in macrophages and to evaluate the involvement of this pathway in phagocytosis of apoptotic neutrophils
23119050Results show that hypoxia increases neutrophil phagocytosis by macrophages and induces the expression of CD36 and TSP-1
23119050Addition of a p38-MAPK inhibitor significantly reduced the increase in CD36 and TSP-1 expression provoked by hypoxia and decreased HIF-1alpha stabilization in macrophages
23119050Transient transfection of macrophages with a miHIF-1alpha-targeting vector blocked the increase in mRNA expression of CD36 and TSP-1 during hypoxia and reduced phagocytosis, thus highlighting a role for the transcriptional activity of HIF-1
23119050CD36 and TSP-1 were necessary for the phagocytosis of neutrophils induced by hypoxic macrophages, since functional blockade of these proteins undermined this process
22258036Furthermore, DNA methylation levels of genes related to development of most or all tumor types, such as BRCA1, CCNA1, CDKN2A (p16), THBS1, TNFRSF10C and TNFRSF10D, were increased in BPA-exposed HMEC
21037952Cell-autonomous and cell-dependent mechanisms have both been implicated, and recent results suggest a critical role for autocrine factors, including thrombospondin-1 and TGF-beta
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