HCSGD entry for TH

1. General information

Official gene symbolTH
Entrez ID7054
Gene full nametyrosine hydroxylase
Other gene symbolsDYT14 DYT5b TYH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIDAbiological_process
GO:0001963Synaptic transmission, dopaminergicISSbiological_process
GO:0001975Response to amphetamineIEAbiological_process
GO:0003007Heart morphogenesisNASbiological_process
GO:0004511Tyrosine 3-monooxygenase activityIDA IEA TASmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005790Smooth endoplasmic reticulumIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006585Dopamine biosynthetic process from tyrosineNASbiological_process
GO:0006631Fatty acid metabolic processIEAbiological_process
GO:0006665Sphingolipid metabolic processIEAbiological_process
GO:0007507Heart developmentISSbiological_process
GO:0007601Visual perceptionISSbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0007612LearningISSbiological_process
GO:0007613MemoryISSbiological_process
GO:0007617Mating behaviorIEAbiological_process
GO:0007626Locomotory behaviorISSbiological_process
GO:0008016Regulation of heart contractionISSbiological_process
GO:0008021Synaptic vesicleIEAcellular_component
GO:0008198Ferrous iron bindingIEAmolecular_function
GO:0008199Ferric iron bindingIEAmolecular_function
GO:0009072Aromatic amino acid family metabolic processIEAbiological_process
GO:0009414Response to water deprivationIEAbiological_process
GO:0009416Response to light stimulusIEAbiological_process
GO:0009635Response to herbicideIEAbiological_process
GO:0009651Response to salt stressIEAbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0009887Organ morphogenesisISSbiological_process
GO:0009898Cytoplasmic side of plasma membraneIDAcellular_component
GO:0010043Response to zinc ionIEAbiological_process
GO:0010259Multicellular organismal agingIEAbiological_process
GO:0014823Response to activityIEAbiological_process
GO:0015842Synaptic vesicle amine transportIEAbiological_process
GO:0016137Glycoside metabolic processIEAbiological_process
GO:0016597Amino acid bindingIEAmolecular_function
GO:0016714Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygenIEAmolecular_function
GO:0018963Phthalate metabolic processIEAbiological_process
GO:0019825Oxygen bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0021987Cerebral cortex developmentIEAbiological_process
GO:0030425DendriteIEAcellular_component
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0031667Response to nutrient levelsIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0033076Isoquinoline alkaloid metabolic processIEAbiological_process
GO:0033162Melanosome membraneIDAcellular_component
GO:0034617Tetrahydrobiopterin bindingIEAmolecular_function
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0035176Social behaviorIEAbiological_process
GO:0035240Dopamine bindingIEAmolecular_function
GO:0035690Cellular response to drugIEAbiological_process
GO:0042136Neurotransmitter biosynthetic processIEAbiological_process
GO:0042214Terpene metabolic processIEAbiological_process
GO:0042416Dopamine biosynthetic processIDAbiological_process
GO:0042418Epinephrine biosynthetic processIDAbiological_process
GO:0042421Norepinephrine biosynthetic processIDAbiological_process
GO:0042423Catecholamine biosynthetic processTASbiological_process
GO:0042462Eye photoreceptor cell developmentISSbiological_process
GO:0042745Circadian sleep/wake cycleIEAbiological_process
GO:0042755Eating behaviorIEAbiological_process
GO:0043005Neuron projectionIDAcellular_component
GO:0043195Terminal boutonIEAcellular_component
GO:0043204PerikaryonISScellular_component
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0043473PigmentationTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045471Response to ethanolIDAbiological_process
GO:0045472Response to etherIEAbiological_process
GO:0046684Response to pyrethroidIEAbiological_process
GO:0048596Embryonic camera-type eye morphogenesisISSbiological_process
GO:0051412Response to corticosteroneIEAbiological_process
GO:0051602Response to electrical stimulusIEAbiological_process
GO:0052314Phytoalexin metabolic processIEAbiological_process
GO:0071287Cellular response to manganese ionIEAbiological_process
GO:0071316Cellular response to nicotineIEAbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.35246623230.89604486910.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1582796542
GSE13712_SHEARUp0.0791581911
GSE13712_STATICUp0.1514092140
GSE19018Up0.2397376836
GSE19899_A1Down-0.1200868615
GSE19899_A2Down-0.0928521815
PubMed_21979375_A1Up0.0069857379
PubMed_21979375_A2Up0.3525365076
GSE35957Up0.1244203489
GSE36640Down-0.0215589822
GSE54402Up0.1526133350
GSE9593Up0.0702654398
GSE43922Up0.1012425350
GSE24585Up0.1343274155
GSE37065Up0.0485781307
GSE28863_A1Down-0.0513695082
GSE28863_A2Up0.1229271274
GSE28863_A3Up0.3648752741
GSE28863_A4Down-0.0335901136
GSE48662Down-0.1266415051

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-PhenylalanineDB00120 NUTR00044
Meta-TyrosineDB03552 EXPT02254
7,8-DihydrobiopterinDB04400 EXPT01697 | DB03271 | EXPT01698

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.