HCSGD entry for TGM1
1. General information
| Official gene symbol | TGM1 |
|---|---|
| Entrez ID | 7051 |
| Gene full name | transglutaminase 1 |
| Other gene symbols | ARCI1 ICR2 KTG LI LI1 TGASE TGK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001533 | Cornified envelope | TAS | cellular_component |
| GO:0003810 | Protein-glutamine gamma-glutamyltransferase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005913 | Cell-cell adherens junction | IEA | cellular_component |
| GO:0006464 | Cellular protein modification process | NAS | biological_process |
| GO:0009887 | Organ morphogenesis | IEA | biological_process |
| GO:0018149 | Peptide cross-linking | IEA | biological_process |
| GO:0030216 | Keratinocyte differentiation | IDA | biological_process |
| GO:0031224 | Intrinsic component of membrane | IDA | cellular_component |
| GO:0031424 | Keratinization | IEA | biological_process |
| GO:0043163 | Cell envelope organization | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6318632993 | 0.8479898978 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0535275258 |
| GSE13712_SHEAR | Up | 0.1810607659 |
| GSE13712_STATIC | Up | 0.0867131734 |
| GSE19018 | Up | 0.0025390507 |
| GSE19899_A1 | Up | 0.0812775821 |
| GSE19899_A2 | Up | 0.2452810613 |
| PubMed_21979375_A1 | Down | -0.0338874604 |
| PubMed_21979375_A2 | Down | -0.0500632469 |
| GSE35957 | Down | -0.0609832376 |
| GSE36640 | Up | 0.1232540390 |
| GSE54402 | Down | -0.0768913807 |
| GSE9593 | Up | 0.0896806059 |
| GSE43922 | Up | 0.0361556963 |
| GSE24585 | Down | -0.0841559336 |
| GSE37065 | Up | 0.1342393072 |
| GSE28863_A1 | Down | -0.1468763328 |
| GSE28863_A2 | Down | -0.1859250773 |
| GSE28863_A3 | Up | 0.1711863524 |
| GSE28863_A4 | Up | 0.1133358619 |
| GSE48662 | Down | -0.0760367809 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022617 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029438 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22686306 | These data were confirmed by a fall in mRNA expression levels of keratin 1 and transglutaminase 1 within the passages |
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