HCSGD entry for TGFBR2

1. General information

Official gene symbolTGFBR2
Entrez ID7048
Gene full nametransforming growth factor, beta receptor II (70/80kDa)
Other gene symbolsAAT3 FAA3 LDS1B LDS2B MFS2 RIIC TAAD2 TGFR-2 TGFbeta-RII
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001568Blood vessel developmentTASbiological_process
GO:0001569Patterning of blood vesselsISSbiological_process
GO:0001570VasculogenesisISSbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationISSbiological_process
GO:0002088Lens development in camera-type eyeIEAbiological_process
GO:0002651Positive regulation of tolerance induction to self antigenISSbiological_process
GO:0002663Positive regulation of B cell tolerance inductionISSbiological_process
GO:0002666Positive regulation of T cell tolerance inductionISSbiological_process
GO:0004675Transmembrane receptor protein serine/threonine kinase activityIDAmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIEAmolecular_function
GO:0005024Transforming growth factor beta-activated receptor activityIC IDA IMPmolecular_function
GO:0005026Transforming growth factor beta receptor activity, type IIIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005539Glycosaminoglycan bindingIDAmolecular_function
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005901CaveolaIDAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006898Receptor-mediated endocytosisIEAbiological_process
GO:0006915Apoptotic processIDAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIC IDA IMP TASbiological_process
GO:0007182Common-partner SMAD protein phosphorylationIEAbiological_process
GO:0007224Smoothened signaling pathwayIEAbiological_process
GO:0007369GastrulationIEAbiological_process
GO:0007420Brain developmentISSbiological_process
GO:0007507Heart developmentISSbiological_process
GO:0007566Embryo implantationIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0010634Positive regulation of epithelial cell migrationIEAbiological_process
GO:0016021Integral component of membraneIDAcellular_component
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0018107Peptidyl-threonine phosphorylationIDAbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0031435Mitogen-activated protein kinase kinase kinase bindingIEAmolecular_function
GO:0032147Activation of protein kinase activityISSbiological_process
GO:0034713Type I transforming growth factor beta receptor bindingIDA IPImolecular_function
GO:0034714Type III transforming growth factor beta receptor bindingIDAmolecular_function
GO:0035162Embryonic hemopoiesisISSbiological_process
GO:0042060Wound healingIEAbiological_process
GO:0042127Regulation of cell proliferationISSbiological_process
GO:0042493Response to drugIDAbiological_process
GO:0043011Myeloid dendritic cell differentiationISSbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0043415Positive regulation of skeletal muscle tissue regenerationIEAbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048565Digestive tract developmentIEAbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
GO:0048701Embryonic cranial skeleton morphogenesisISSbiological_process
GO:0050431Transforming growth factor beta bindingIDA IPImolecular_function
GO:0051138Positive regulation of NK T cell differentiationISSbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0060021Palate developmentISSbiological_process
GO:0060044Negative regulation of cardiac muscle cell proliferationIEAbiological_process
GO:0060389Pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0060434Bronchus morphogenesisIEAbiological_process
GO:0060440Trachea formationIEAbiological_process
GO:0060443Mammary gland morphogenesisIEAbiological_process
GO:0060463Lung lobe morphogenesisIEAbiological_process
GO:0070022Transforming growth factor beta receptor homodimeric complexICcellular_component
GO:0070723Response to cholesterolIDAbiological_process
GO:1990086Lens fiber cell apoptotic processIEAbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00545103150.92839523570.19421799731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0643632850
GSE13712_SHEARUp0.0757181912
GSE13712_STATICUp0.1906379781
GSE19018Down-0.2063508281
GSE19899_A1Up0.2790427924
GSE19899_A2Up0.8706694131
PubMed_21979375_A1Up0.3047288930
PubMed_21979375_A2Up0.8092442551
GSE35957Up1.4921011264
GSE36640Up1.9830152310
GSE54402Down-0.4269655005
GSE9593Up1.9330610446
GSE43922Up0.3150925592
GSE24585Down-0.1349735559
GSE37065Down-0.1125242869
GSE28863_A1Up0.2162344963
GSE28863_A2Up0.6848008211
GSE28863_A3Down-0.0201826861
GSE28863_A4Down-0.1366513154
GSE48662Down-0.0158367515

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1908395CHEMBL42679P37173
CHEMBL31965CHEMBL42679P37173
CHEMBL1287853CHEMBL42679P37173
CHEMBL428690CHEMBL42679P37173
CHEMBL31965CHEMBL42679P37173
CHEMBL1421CHEMBL42679P37173
CHEMBL1336CHEMBL42679P37173
CHEMBL475251CHEMBL42679P37173
CHEMBL296468CHEMBL42679P37173
CHEMBL574738CHEMBL42679P37173
CHEMBL574738CHEMBL42679P37173
CHEMBL10CHEMBL42679P37173
CHEMBL477772CHEMBL42679P37173
CHEMBL1908396CHEMBL42679P37173
CHEMBL603469CHEMBL42679P37173
CHEMBL1241674CHEMBL42679P37173
CHEMBL509032CHEMBL42679P37173
CHEMBL296468CHEMBL42679P37173
CHEMBL1230020CHEMBL42679P37173
CHEMBL10CHEMBL42679P37173
CHEMBL428690CHEMBL42679P37173
CHEMBL1421CHEMBL42679P37173
CHEMBL386051CHEMBL42679P37173
CHEMBL204063CHEMBL42679P37173
CHEMBL204170CHEMBL42679P37173
CHEMBL378167CHEMBL42679P37173
CHEMBL381532CHEMBL42679P37173
CHEMBL203214CHEMBL42679P37173
CHEMBL382838CHEMBL42679P37173
CHEMBL202625CHEMBL42679P37173
CHEMBL203619CHEMBL42679P37173
CHEMBL204139CHEMBL42679P37173
CHEMBL261454CHEMBL42679P37173
CHEMBL204966CHEMBL42679P37173
CHEMBL603469CHEMBL42678P37173
CHEMBL496862CHEMBL42678P37173
CHEMBL1615182CHEMBL42678P37173
CHEMBL186290CHEMBL42677P37173
CHEMBL362588CHEMBL42677P37173
CHEMBL178737CHEMBL42677P37173
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  • Drugs

Name

Drug

Accession number

GlycerolDB04077 EXPT01027

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT001189qRT-PCR//Western blotFunctional MTI19906824
hsa-miR-21-5pMIMAT0000076MIRT001189qRT-PCR//Luciferase reporter assay//Western blot//Reporter assayFunctional MTI19816956
hsa-miR-21-5pMIMAT0000076MIRT001189Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI18829576
hsa-miR-21-5pMIMAT0000076MIRT001189Luciferase reporter assay//Western blotFunctional MTI22072622
hsa-miR-21-5pMIMAT0000076MIRT001189MicroarrayFunctional MTI (Weak)18591254
hsa-miR-20a-5pMIMAT0000075MIRT001785Immunoblot//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20940405
hsa-miR-20a-5pMIMAT0000075MIRT001785Microarray//qRT-PCRFunctional MTI (Weak)19435428
hsa-miR-20a-5pMIMAT0000075MIRT001785Luciferase reporter assay//Microarray//Reporter assayFunctional MTI16461460
hsa-miR-204-5pMIMAT0000265MIRT003272Luciferase reporter assayFunctional MTI20056717
hsa-miR-204-5pMIMAT0000265MIRT003272MicroarrayFunctional MTI (Weak)21282569
hsa-miR-17-5pMIMAT0000070MIRT004591Immunoblot//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20940405
hsa-miR-18a-5pMIMAT0000072MIRT004592Luciferase reporter assay//MicroarrayNon-Functional MTI20940405
hsa-miR-19a-3pMIMAT0000073MIRT004593Luciferase reporter assay//MicroarrayNon-Functional MTI20940405
hsa-miR-19b-3pMIMAT0000074MIRT004594Microarray//qRT-PCRFunctional MTI (Weak)19435428
hsa-miR-19b-3pMIMAT0000074MIRT004594SequencingFunctional MTI (Weak)20371350
hsa-miR-590-5pMIMAT0003258MIRT004619Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19398468
hsa-miR-92a-3pMIMAT0000092MIRT004737Microarray//qRT-PCRFunctional MTI (Weak)19435428
hsa-miR-92a-3pMIMAT0000092MIRT004737Luciferase reporter assay//MicroarrayNon-Functional MTI20940405
hsa-miR-302b-3pMIMAT0000715MIRT005930Immunocytochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI21490602
hsa-miR-372-3pMIMAT0000724MIRT005931Immunocytochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI21490602
hsa-miR-335-5pMIMAT0000765MIRT016729MicroarrayFunctional MTI (Weak)18185580
hsa-miR-130b-3pMIMAT0000691MIRT020143SequencingFunctional MTI (Weak)20371350
hsa-miR-93-5pMIMAT0000093MIRT027974SequencingFunctional MTI (Weak)20371350
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-26a-5pMIMAT0000082NAhsa-miR-26a{activity assay}{overexpression by mature miRNA transfection}{luciferase}16461460
hsa-miR-21-5pMIMAT0000076NAhsa-miR-21{Western blot}{overexpression by miRNA precursor transfection}19906824
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17662305TGF-beta1, TGFbeta-RI, TGFbeta-RII, and Col1 A1 mRNA levels were analyzed by real-time PCR
17662305There were no statistically significant differences in TGF-beta1, TGFbeta-RI, TGFbeta-RII, and Col1 A1 mRNA levels between HDFs that were transfected with Ad-hTERT and those that were transfected with Ad-NULL after TGF-beta1 treatment
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