HCSGD entry for TGFB1I1
1. General information
| Official gene symbol | TGFB1I1 |
|---|---|
| Entrez ID | 7041 |
| Gene full name | transforming growth factor beta 1 induced transcript 1 |
| Other gene symbols | ARA55 HIC-5 HIC5 TSC-5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003713 | Transcription coactivator activity | IDA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005925 | Focal adhesion | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007155 | Cell adhesion | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0009408 | Response to heat | IEA | biological_process |
| GO:0010718 | Positive regulation of epithelial to mesenchymal transition | IDA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0016331 | Morphogenesis of embryonic epithelium | IEA | biological_process |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0030511 | Positive regulation of transforming growth factor beta receptor signaling pathway | IDA | biological_process |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | IDA | biological_process |
| GO:0030521 | Androgen receptor signaling pathway | NAS | biological_process |
| GO:0030579 | Ubiquitin-dependent SMAD protein catabolic process | IDA | biological_process |
| GO:0030855 | Epithelial cell differentiation | IEA | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0045165 | Cell fate commitment | IEA | biological_process |
| GO:0045599 | Negative regulation of fat cell differentiation | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA NAS | biological_process |
| GO:0048495 | Roundabout binding | IPI | molecular_function |
| GO:0050681 | Androgen receptor binding | IPI NAS | molecular_function |
| GO:0070411 | I-SMAD binding | IEA IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9962816306 | 0.0004835645 | 0.9999902473 | 0.0411066038 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.0144015188 |
| GSE13712_SHEAR | Down | -0.1688098333 |
| GSE13712_STATIC | Down | -0.3316102522 |
| GSE19018 | Down | -0.5676170588 |
| GSE19899_A1 | Down | -1.9744204023 |
| GSE19899_A2 | Down | -0.9224146847 |
| PubMed_21979375_A1 | Down | -2.4610161845 |
| PubMed_21979375_A2 | Down | -0.9804209312 |
| GSE35957 | Down | -0.8478091998 |
| GSE36640 | Down | -0.7177012441 |
| GSE54402 | Down | -0.5987477859 |
| GSE9593 | Down | -0.4638586835 |
| GSE43922 | Down | -0.9567216787 |
| GSE24585 | Up | 0.5316966481 |
| GSE37065 | Down | -0.6002942817 |
| GSE28863_A1 | Up | 0.0315181851 |
| GSE28863_A2 | Down | -0.2988907202 |
| GSE28863_A3 | Down | -0.0504901961 |
| GSE28863_A4 | Down | -0.2180145183 |
| GSE48662 | Down | -0.1952453217 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022662 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029598 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15610763 | Genes specifically up-regulated by transdifferentiation but not by cellular senescence of PrSCs were metalloproteinase 1 tissue inhibitor (Timp1), transgelin (Tagln), gamma 2 actin (Actg2), plasminogen activator inhibitor 1 (Serpinel), insulin-like growth factor binding protein 3 (Igfbp3), parathyroid hormone-like hormone (Pthlp), Tgfb-1, four and a half LIM domains 2 (Fhl-2), hydrogen peroxide-inducible clone 5 (Hic5) and cartilage oligomeric matrix protein (Comp) |
| 11937715 | Hic-5, a focal adhesion protein, has been implicated in cellular senescence and differentiation |
| 10848625 | Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix |
| 10848625 | Hic-5 (hydrogen peroxide-inducible clone-5) is a focal adhesion protein that is involved in cellular senescence |
| 10848625 | In the present study, a yeast two-hybrid screen identified Hic-5 as a protein that interacts with a region of the glucocorticoid receptor that includes a nuclear matrix-targeting signal and the tau2 transcriptional activation domain |
| 10848625 | In transiently transfected mammalian cells, overexpression of Hic-5 potentiated the activation of reporter genes by all steroid receptors, excluding the estrogen receptor |
| 10848625 | In biochemical fractionations and indirect immunofluorescence assays, a fraction of endogenous Hic-5 in REF-52 cells and transiently expressed Hic-5 in Cos-1 cells was associated with the nuclear matrix |
| 10848625 | The C-terminal region of Hic-5, which contains seven zinc fingers arranged in four LIM domains, was required for interaction with focal adhesions, the nuclear matrix, steroid receptors, and the tau2 domain of glucocorticoid receptor |
| 10848625 | The N-terminal region of Hic-5 possesses a transcriptional activation domain and was essential for the coactivator activity of Hic-5 |
| 10848625 | Given the coexisting cytoplasmic and nuclear distributions of Hic-5 and its role in steroid receptor-mediated transcriptional activation, it is proposed that Hic-5 might transmit signals that emanate at cell attachment sites and regulate transcription factors, such as steroid receptors |
| 10708479 | Molecular cloning of human Hic-5, a potential regulator involved in signal transduction and cellular senescence |
| 10708479 | By using differential display, we cloned the human counterpart of the murine gene Hic-5 from senescent human keratinocytes |
| 10708479 | Hic-5 may therefore function, like paxillin, as a potential adapter for the recruitment of structural and signaling molecules to certain subcellular sites or in focal adhesions |
| 10708479 | Fluorescent in situ hybridization by using a human Hic-5 specific probe localized the gene to human chromosome 16p11 |
| 9032249 | HIC-5 was localized in nuclei and had affinity for DNA |
| 9032249 | Based on these observations, we speculated that HIC-5 affected the expression of senescence-related genes through interacting with DNA and thereby induced the senescence-like phenotypes |
| 7929412 | Analysis of this cDNA renamed hic (hydrogen peroxide-inducible clone)-5 suggested that Hic-5 protein has four LIM motifs, each of which contained two (or one) putative zinc fingers |
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