HCSGD entry for TFF2
1. General information
| Official gene symbol | TFF2 |
|---|---|
| Entrez ID | 7032 |
| Gene full name | trefoil factor 2 |
| Other gene symbols | SML1 SP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0007586 | Digestion | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0019722 | Calcium-mediated signaling | IEA | biological_process |
| GO:0030334 | Regulation of cell migration | IEA | biological_process |
| GO:0031723 | CXCR4 chemokine receptor binding | IEA | molecular_function |
| GO:0043031 | Negative regulation of macrophage activation | IEA | biological_process |
| GO:0050728 | Negative regulation of inflammatory response | IEA | biological_process |
| GO:0060455 | Negative regulation of gastric acid secretion | IEA | biological_process |
| GO:0070098 | Chemokine-mediated signaling pathway | IEA | biological_process |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7482468181 | 0.4756370085 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0097307685 |
| GSE13712_SHEAR | Down | -0.0915869568 |
| GSE13712_STATIC | Down | -0.1277286362 |
| GSE19018 | Down | -0.0242740976 |
| GSE19899_A1 | Up | 0.0052731150 |
| GSE19899_A2 | Up | 0.0399080709 |
| PubMed_21979375_A1 | Down | -0.1856791151 |
| PubMed_21979375_A2 | Down | -0.1778266382 |
| GSE35957 | Up | 0.6802567257 |
| GSE36640 | Down | -0.0008348953 |
| GSE54402 | Down | -0.0927300198 |
| GSE9593 | Down | -0.0396813504 |
| GSE43922 | Up | 0.0456469629 |
| GSE24585 | Down | -0.0342139531 |
| GSE37065 | Down | -0.0444478656 |
| GSE28863_A1 | Down | -0.1536227222 |
| GSE28863_A2 | Down | -0.3280356138 |
| GSE28863_A3 | Up | 0.2457643022 |
| GSE28863_A4 | Up | 0.1436184273 |
| GSE48662 | Up | 0.0126112642 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Pyroglutamic Acid | DB03088 | EXPT00247 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT006110 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27161319 | This synthetic-lethality phenotype was as pronounced as that caused by extensive DNA damage in wild-type cells but showed genetic dependencies distinct from such damage and was completely alleviated by SML1 deletion, which increases deoxynucleoside triphosphate (dNTP) pools |
| 27161319 | We propose that normally occurring telomeric DNA replication stress is resolved by telomerase activity and the DDR in two parallel pathways and that deletion of Sml1 prevents this stress |
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