HCSGD entry for TFE3
1. General information
| Official gene symbol | TFE3 |
|---|---|
| Entrez ID | 7030 |
| Gene full name | transcription factor binding to IGHM enhancer 3 |
| Other gene symbols | RCCP2 RCCX1 TFEA bHLHe33 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | ISS | molecular_function |
| GO:0005634 | Nucleus | IDA IMP | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006959 | Humoral immune response | ISS | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | ISS | molecular_function |
| GO:0045670 | Regulation of osteoclast differentiation | IEA | biological_process |
| GO:0045785 | Positive regulation of cell adhesion | IMP | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IMP ISS | biological_process |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0869845181 | 0.8378948710 | 0.6187890541 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1660529186 |
| GSE13712_SHEAR | Up | 0.2316346061 |
| GSE13712_STATIC | Up | 0.2682610549 |
| GSE19018 | Up | 0.1402968110 |
| GSE19899_A1 | Up | 0.0847904406 |
| GSE19899_A2 | Up | 0.4443804685 |
| PubMed_21979375_A1 | Up | 0.9250256507 |
| PubMed_21979375_A2 | Up | 0.5066877877 |
| GSE35957 | Up | 0.3611179538 |
| GSE36640 | Up | 0.6077726288 |
| GSE54402 | Up | 0.3707524623 |
| GSE9593 | Up | 0.1615938806 |
| GSE43922 | Down | -0.0502432066 |
| GSE24585 | Down | -0.3411471084 |
| GSE37065 | Down | -0.1954229151 |
| GSE28863_A1 | Down | -0.0509741675 |
| GSE28863_A2 | Down | -0.0165199481 |
| GSE28863_A3 | Down | -0.4374441882 |
| GSE28863_A4 | Down | -0.1550412483 |
| GSE48662 | Up | 0.2477360125 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017158 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037852 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26003288 | Other MiT members, TFEB and TFE3, are known to play important roles in cellular clearance pathways by transcriptionally regulating the biogenesis of lysosomes and autophagosomes via activation of CLEAR elements in gene promoters of target genes |
| 26003288 | Here we review the role of MiT members, including MITF, in lysosomal biogenesis, and how cancers overexpressing MITF, TFEB or TFE3 could rewire the lysosomal pathway, inhibit cellular senescence, and activate Wnt signaling by increasing sequestration of negative regulators of Wnt signaling in multivesicular bodies (MVBs) |
| 21258399 | The identification of MITF-binding sites and gene-regulatory networks establish a framework for understanding oncogenic basic helix-loop-helix factors such as N-myc or TFE3 in other cancers |
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