HCSGD entry for TFAP4

1. General information

Official gene symbolTFAP4
Entrez ID7023
Gene full nametranscription factor AP-4 (activating enhancer binding protein 4)
Other gene symbolsAP-4 bHLHc41
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006461Protein complex assemblyIDA IEAbiological_process
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIDAbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0017053Transcriptional repressor complexIEA ISScellular_component
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0042826Histone deacetylase bindingIEA IPImolecular_function
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043392Negative regulation of DNA bindingIDAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0043922Negative regulation by host of viral transcriptionIDA NASbiological_process
GO:0043923Positive regulation by host of viral transcriptionIDAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045736Negative regulation of cyclin-dependent protein serine/threonine kinase activityIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IEA IMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0046982Protein heterodimerization activityIMPmolecular_function
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0070888E-box bindingIDA IEAmolecular_function
GO:0071157Negative regulation of cell cycle arrestIMPbiological_process
GO:0071549Cellular response to dexamethasone stimulusIEAbiological_process
GO:2001269Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66128599220.23518974200.99999024730.9331367501

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0824536657
GSE13712_SHEARUp0.2620143587
GSE13712_STATICUp0.1143957749
GSE19018Down-0.1144915132
GSE19899_A1Down-0.2992132537
GSE19899_A2Up0.3584215485
PubMed_21979375_A1Up0.0779906153
PubMed_21979375_A2Down-0.3658157498
GSE35957Up0.2932441302
GSE36640Down-0.0934833654
GSE54402Down-0.1892086530
GSE9593Up0.0038738698
GSE43922Down-0.1113012014
GSE24585Down-0.6092622481
GSE37065Down-0.2262424396
GSE28863_A1Up0.2295590496
GSE28863_A2Up0.1772644233
GSE28863_A3Up0.2802211074
GSE28863_A4Up0.0212810336
GSE48662Up0.0448321047

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-373-3pMIMAT0000726MIRT002538Microarray//Microarray;OtherFunctional MTI (Weak)15685193
hsa-miR-335-5pMIMAT0000765MIRT018094MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT022725Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-101-3pMIMAT0000099MIRT027354SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031768ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-373-3pMIMAT0000726NAhsa-miR-37315685193
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.