HCSGD entry for TFAP2C

1. General information

Official gene symbolTFAP2C
Entrez ID7022
Gene full nametranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Other gene symbolsAP2-GAMMA ERF1 TFAP2G hAP-2g
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0001829Trophectodermal cell differentiationIEAbiological_process
GO:0001942Hair follicle developmentIEAbiological_process
GO:0003334Keratinocyte developmentIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008584Male gonad developmentIEPbiological_process
GO:0021877Forebrain neuron fate commitmentIEAbiological_process
GO:0021987Cerebral cortex developmentIEAbiological_process
GO:0030718Germ-line stem cell maintenanceIEAbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0045682Regulation of epidermis developmentIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0046983Protein dimerization activityIDAmolecular_function
GO:0048733Sebaceous gland developmentIEAbiological_process
GO:0060598Dichotomous subdivision of terminal units involved in mammary gland duct morphogenesisIEAbiological_process
GO:0060750Epithelial cell proliferation involved in mammary gland duct elongationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00225583750.99747117130.12741609441.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0397574452
GSE13712_SHEARUp0.0806722638
GSE13712_STATICUp0.0461271318
GSE19018Down-0.0290578687
GSE19899_A1Up0.4472351527
GSE19899_A2Up1.8815369753
PubMed_21979375_A1Up1.8810581046
PubMed_21979375_A2Up2.5200764782
GSE35957Up0.0715601152
GSE36640Up1.1787398603
GSE54402Up1.6779699048
GSE9593Up0.2042678335
GSE43922Up0.5901104524
GSE24585Up0.3393342474
GSE37065Up0.0092512394
GSE28863_A1Up0.2947229515
GSE28863_A2Up0.2953339489
GSE28863_A3Up0.1524753152
GSE28863_A4Up0.0774970305
GSE48662Up0.0490394113

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29c-3pMIMAT0000681MIRT006384Luciferase reporter assayFunctional MTI21436257
hsa-miR-10b-5pMIMAT0000254MIRT006367Luciferase reporter assay//Western blotFunctional MTI21471404
hsa-miR-10a-5pMIMAT0000253MIRT025625SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.