HCSGD entry for TFAP2B

1. General information

Official gene symbolTFAP2B
Entrez ID7021
Gene full nametranscription factor AP-2 beta (activating enhancer binding protein 2 beta)
Other gene symbolsAP-2B AP2-B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIDAmolecular_function
GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activityISSmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001105RNA polymerase II transcription coactivator activityISSmolecular_function
GO:0001106RNA polymerase II transcription corepressor activityISSmolecular_function
GO:0001158Enhancer sequence-specific DNA bindingIDAmolecular_function
GO:0001822Kidney developmentISSbiological_process
GO:0003091Renal water homeostasisISSbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0003714Transcription corepressor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIC IDAcellular_component
GO:0006006Glucose metabolic processIMPbiological_process
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0010226Response to lithium ionIEAbiological_process
GO:0010842Retina layer formationIEPbiological_process
GO:0010960Magnesium ion homeostasisISSbiological_process
GO:0030510Regulation of BMP signaling pathwayISSbiological_process
GO:0035136Forelimb morphogenesisISSbiological_process
GO:0035137Hindlimb morphogenesisISSbiological_process
GO:0035810Positive regulation of urine volumeISSbiological_process
GO:0035909Aorta morphogenesisISSbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042593Glucose homeostasisISSbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043027Cysteine-type endopeptidase inhibitor activity involved in apoptotic processISSmolecular_function
GO:0043066Negative regulation of apoptotic processIDA ISSbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processISSbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043525Positive regulation of neuron apoptotic processIDAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0043588Skin developmentIEAbiological_process
GO:0045444Fat cell differentiationIEPbiological_process
GO:0045595Regulation of cell differentiationIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0046983Protein dimerization activityIDAmolecular_function
GO:0048485Sympathetic nervous system developmentISSbiological_process
GO:0050796Regulation of insulin secretionIMPbiological_process
GO:0055062Phosphate ion homeostasisISSbiological_process
GO:0055074Calcium ion homeostasisISSbiological_process
GO:0055075Potassium ion homeostasisISSbiological_process
GO:0055078Sodium ion homeostasisISSbiological_process
GO:0072017Distal tubule developmentISSbiological_process
GO:0072044Collecting duct developmentISSbiological_process
GO:0072210Metanephric nephron developmentIEAbiological_process
GO:0097070Ductus arteriosus closureISSbiological_process
GO:0097275Cellular ammonia homeostasisISSbiological_process
GO:0097276Cellular creatinine homeostasisISSbiological_process
GO:0097277Cellular urea homeostasisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57213078150.93128895940.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0220062112
GSE13712_SHEARDown-0.0526365607
GSE13712_STATICUp0.0007014258
GSE19018Up0.0741061157
GSE19899_A1Up0.0914966073
GSE19899_A2Up0.1002177999
PubMed_21979375_A1Up0.1435643601
PubMed_21979375_A2Down-0.0190260280
GSE35957Up0.1130514301
GSE36640Up0.0489451045
GSE54402Up0.0506545557
GSE9593Up0.0192376406
GSE43922Up0.0165100031
GSE24585Up0.1490865483
GSE37065Down-0.0126122781
GSE28863_A1Down-0.0043581092
GSE28863_A2Up0.0010411349
GSE28863_A3Up0.2842357107
GSE28863_A4Up0.0717939824
GSE48662Down-0.0305829821

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017509MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.