HCSGD entry for TFAP2A

1. General information

Official gene symbolTFAP2A
Entrez ID7020
Gene full nametranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Other gene symbolsAP-2 AP-2alpha AP2TF BOFS TFAP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000976Transcription regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIDAmolecular_function
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0000987Core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0001105RNA polymerase II transcription coactivator activityIEAmolecular_function
GO:0001106RNA polymerase II transcription corepressor activityIEAmolecular_function
GO:0001822Kidney developmentIMPbiological_process
GO:0003151Outflow tract morphogenesisIEAbiological_process
GO:0003334Keratinocyte developmentIEAbiological_process
GO:0003404Optic vesicle morphogenesisISSbiological_process
GO:0003409Optic cup structural organizationISSbiological_process
GO:0003682Chromatin bindingISSmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEA IMPcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0007605Sensory perception of soundIMPbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0009880Embryonic pattern specificationIEAbiological_process
GO:0010172Embryonic body morphogenesisIEAbiological_process
GO:0010628Positive regulation of gene expressionISSbiological_process
GO:0010842Retina layer formationIEPbiological_process
GO:0010944Negative regulation of transcription by competitive promoter bindingIDA IMPbiological_process
GO:0014032Neural crest cell developmentIEAbiological_process
GO:0021506Anterior neuropore closureIEAbiological_process
GO:0021559Trigeminal nerve developmentISSbiological_process
GO:0021623Oculomotor nerve formationISSbiological_process
GO:0021884Forebrain neuron developmentIEAbiological_process
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0030501Positive regulation of bone mineralizationIDAbiological_process
GO:0035115Embryonic forelimb morphogenesisISSbiological_process
GO:0042059Negative regulation of epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0042472Inner ear morphogenesisIMPbiological_process
GO:0042803Protein homodimerization activityTASmolecular_function
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043525Positive regulation of neuron apoptotic processIDAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045595Regulation of cell differentiationIDAbiological_process
GO:0045664Regulation of neuron differentiationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046983Protein dimerization activityIDAmolecular_function
GO:0048485Sympathetic nervous system developmentIEAbiological_process
GO:0048701Embryonic cranial skeleton morphogenesisISSbiological_process
GO:0048730Epidermis morphogenesisIEAbiological_process
GO:0060021Palate developmentIMPbiological_process
GO:0060235Lens induction in camera-type eyeIEAbiological_process
GO:0060325Face morphogenesisIEAbiological_process
GO:0060349Bone morphogenesisISSbiological_process
GO:0061029Eyelid development in camera-type eyeISSbiological_process
GO:0061303Cornea development in camera-type eyeIEAbiological_process
GO:0070172Positive regulation of tooth mineralizationIDAbiological_process
GO:0071281Cellular response to iron ionIDAbiological_process
GO:0071711Basement membrane organizationIEAbiological_process
GO:0072210Metanephric nephron developmentIEAbiological_process
GO:2000378Negative regulation of reactive oxygen species metabolic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59110827860.02171358990.99999024730.2840573559

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0618918617
GSE13712_SHEARUp0.0231955638
GSE13712_STATICDown-0.0395059561
GSE19018Up0.0392215724
GSE19899_A1Down-0.1239804687
GSE19899_A2Down-1.1262233115
PubMed_21979375_A1Down-2.6801355226
PubMed_21979375_A2Down-1.3220601244
GSE35957Up0.4394189893
GSE36640Down-0.7042891896
GSE54402Up0.2430967043
GSE9593Down-0.0273953135
GSE43922Down-0.8903633319
GSE24585Up1.7450411802
GSE37065Up0.3083216279
GSE28863_A1Down-0.0148950410
GSE28863_A2Up0.1582452685
GSE28863_A3Down-0.5696062786
GSE28863_A4Down-0.1634767973
GSE48662Down-0.2000989690

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-221-3pMIMAT0000278MIRT024195SequencingFunctional MTI (Weak)20371350
hsa-miR-103a-3pMIMAT0000101MIRT027191SequencingFunctional MTI (Weak)20371350
hsa-miR-98-5pMIMAT0000096MIRT027773MicroarrayFunctional MTI (Weak)19088304
hsa-miR-16-5pMIMAT0000069MIRT031854SequencingFunctional MTI (Weak)20371350
hsa-miR-320aMIMAT0000510MIRT044482CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

8803927The promoter also contains sites for inducible transcription factors, cAMP-responsive element (CRE)-binding protein (CREB), and Activator protein 2 (AP-2)
1426249There were no differences in c-jun expression and formation of other transcription factors (AP-2 and AP-3) between lymphocytes isolated from old and young mice
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