HCSGD entry for BUB1B
1. General information
| Official gene symbol | BUB1B |
|---|---|
| Entrez ID | 701 |
| Gene full name | BUB1 mitotic checkpoint serine/threonine kinase B |
| Other gene symbols | BUB1beta BUBR1 Bub1A MAD3L MVA1 SSK1 hBUBR1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000776 | Kinetochore | IDA NAS TAS | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IDA | cellular_component |
| GO:0000778 | Condensed nuclear chromosome kinetochore | IEA | cellular_component |
| GO:0000940 | Condensed chromosome outer kinetochore | IDA | cellular_component |
| GO:0004672 | Protein kinase activity | NAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005680 | Anaphase-promoting complex | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007049 | Cell cycle | NAS | biological_process |
| GO:0007051 | Spindle organization | NAS | biological_process |
| GO:0007067 | Mitosis | NAS | biological_process |
| GO:0007091 | Metaphase/anaphase transition of mitotic cell cycle | IEA | biological_process |
| GO:0007093 | Mitotic cell cycle checkpoint | TAS | biological_process |
| GO:0007094 | Mitotic spindle assembly checkpoint | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0031145 | Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0034501 | Protein localization to kinetochore | IPI | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | NAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051233 | Spindle midzone | NAS | cellular_component |
| GO:0051436 | Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0051439 | Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0071459 | Protein localization to chromosome, centromeric region | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9980574826 | 0.0000059800 | 0.9999902473 | 0.0069833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.2427376203 |
| GSE13712_SHEAR | Down | -0.4195506243 |
| GSE13712_STATIC | Down | -0.1913959824 |
| GSE19018 | Up | 0.0503095882 |
| GSE19899_A1 | Down | -2.6716479688 |
| GSE19899_A2 | Down | -4.8536456297 |
| PubMed_21979375_A1 | Down | -4.5286531805 |
| PubMed_21979375_A2 | Down | -5.8808263208 |
| GSE35957 | Down | -5.4824434440 |
| GSE36640 | Down | -5.3740809223 |
| GSE54402 | Down | -1.3751989605 |
| GSE9593 | Down | -2.4122174283 |
| GSE43922 | Down | -2.8587823445 |
| GSE24585 | Down | -0.5525487472 |
| GSE37065 | Down | -1.0427748825 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -1.7698664734 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016386 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016386 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024609 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026320 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT050455 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26883501 | In addition, tight junction coverage in microvessels and BBB integrity in BubR1 hypomorphic (BubR1(H/H)) mice, which display senescence cell-dependent phenotypes, were examined |
| 26847209 | Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence |
| 26847209 | BACKGROUND: Spindle assembly checkpoint components BubR1 and Sgo1 play a key role in the maintenance of chromosomal instability during cell division |
| 26847209 | Haplo-insufficiency of either BubR1 or SGO1 results in enhanced chromosomal instability and tumor development in the intestine |
| 26847209 | METHODS: We took advantage of the availability of BubR1 and SGO1 knockout mice and generated primary murine embryonic fibroblasts (MEFs) with mutations in either BubR1, SGO1, or both and analyzed cellular senescence of the MEFs of various genetic backgrounds |
| 26847209 | RESULTS: We observed that BubR1(+/-) SGO(+/-) MEFs had an accelerated cellular senescence characterized by morphological changes and expressed senescence-associated beta-galactosidase |
| 26847209 | In addition, compared with wild-type MEFs or MEFs with a single gene deficiency, BubR1(+/-) SGO1(+/-) MEFs expressed enhanced levels of p21 but not p16 |
| 26847209 | CONCLUSIONS: Taken together, our observations suggest that combined deficiency of BubR1 and Sgo1 accelerates cellular senescence |
| 23212104 | The use of a progeroid mouse model (which expresses low amounts of the mitotic checkpoint protein BubR1) has been instrumental in demonstrating that p16(Ink4a)-positive senescent cells drive age-related pathologies and that selective elimination of these cells can prevent or delay age-related deterioration |
| 22048312 | Here we show that in the BubR1 progeroid mouse background, INK-ATTAC removes p16(Ink4a)-positive senescent cells upon drug treatment |
| 18769141 | One approach to bypass this problem would be to inactivate these pathways in a murine segmental progeria model such as mice that express low amounts of the mitotic checkpoint protein BubR1 (BubR1 hypomorphic mice) |
| 18769141 | Importantly, BubR1 hypomorphism elevates both p16(Ink4a) and p19(Arf) expression in skeletal muscle and fat |
| 18769141 | Inactivation of p16(Ink4a) in BubR1 mutant mice delays both cellular senescence and aging specifically in these tissues |
| 18516091 | Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency |
| 18516091 | Here, we show that skeletal muscle and fat, two tissues that develop early ageing-associated phenotypes in response to BubR1 insufficiency, have high levels of p16(Ink4a) and p19(Arf) |
| 18516091 | Conversely, p19(Arf) inactivation exacerbates senescence and ageing in BubR1 mutant mice |
| 18516091 | Thus, we identify BubR1 insufficiency as a trigger for activation of the Cdkn2a locus in certain mouse tissues, and demonstrate that p16(Ink4a) is an effector and p19(Arf) an attenuator of senescence and ageing in these tissues |
| 16476774 | Mice that have small amounts of the mitotic checkpoint protein BubR1 age much faster than normal mice, but whether other mitotic checkpoint genes function to prevent the early onset of aging is unknown |
| 16476774 | Furthermore, although BubR1 hypomorphic mice have less aneuploidy than Bub3/Rae1 haploinsufficient mice, they age much faster |
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