HCSGD entry for PRDX2
1. General information
| Official gene symbol | PRDX2 |
|---|---|
| Entrez ID | 7001 |
| Gene full name | peroxiredoxin 2 |
| Other gene symbols | NKEF-B NKEFB PRP PRX2 PRXII PTX1 TDPX1 TPX1 TSA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006979 | Response to oxidative stress | IMP NAS | biological_process |
| GO:0008379 | Thioredoxin peroxidase activity | IDA TAS | molecular_function |
| GO:0016209 | Antioxidant activity | IDA IEA NAS | molecular_function |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0019430 | Removal of superoxide radicals | IDA | biological_process |
| GO:0034599 | Cellular response to oxidative stress | IDA | biological_process |
| GO:0042744 | Hydrogen peroxide catabolic process | TAS | biological_process |
| GO:0042981 | Regulation of apoptotic process | IMP | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1086479921 | 0.9495945557 | 0.6834853327 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1793747665 |
| GSE13712_SHEAR | Down | -0.1805064324 |
| GSE13712_STATIC | Down | -0.2308309155 |
| GSE19018 | Up | 0.1761841072 |
| GSE19899_A1 | Up | 0.2433098202 |
| GSE19899_A2 | Up | 0.4831678834 |
| PubMed_21979375_A1 | Up | 0.4449923272 |
| PubMed_21979375_A2 | Up | 0.2544230194 |
| GSE35957 | Down | -0.1278593538 |
| GSE36640 | Up | 0.2201329818 |
| GSE54402 | Up | 0.2472719219 |
| GSE9593 | Down | -0.0484686652 |
| GSE43922 | Up | 0.2517067567 |
| GSE24585 | Down | -0.2665634094 |
| GSE37065 | Down | -0.0137460965 |
| GSE28863_A1 | Up | 0.0729747542 |
| GSE28863_A2 | Down | -0.0913632227 |
| GSE28863_A3 | Up | 0.4690285033 |
| GSE28863_A4 | Down | -0.0105590429 |
| GSE48662 | Up | 0.3928471000 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023992 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039753 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042800 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046023 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047661 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26696133 | The levels of some antioxidant enzymes, such as catalase, peroxiredoxin II and glutathione peroxidase I, were transiently induced by PPKO treatment |
| 25151118 | The novel role of peroxiredoxin-2 in red cell membrane protein homeostasis and senescence |
| 24616707 | The bulk of the ROS are neutralized by the RBC antioxidant system consisting of both non-enzymatic and enzymatic antioxidants including catalase, glutathione peroxidase and peroxiredoxin-2 |
| 20721618 | Association of creatin kinase B and peroxiredoxin 2 expression with age and embryo quality in cumulus cells |
| 20721618 | RESULTS: CKB and PRDX2 were up-regulated in women older than 38 years, and the expression of these genes in cumulus cells was associated with embryo quality |
| 20721618 | CKB and PRDX2 may serve as biomarkers or therapeutic targets for the developmental potential of oocytes |
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