HCSGD entry for TDO2
1. General information
| Official gene symbol | TDO2 |
|---|---|
| Entrez ID | 6999 |
| Gene full name | tryptophan 2,3-dioxygenase |
| Other gene symbols | TDO TO TPH2 TRPO |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004833 | Tryptophan 2,3-dioxygenase activity | IBA IEA TAS | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006569 | Tryptophan catabolic process | TAS | biological_process |
| GO:0016597 | Amino acid binding | IEA | molecular_function |
| GO:0019441 | Tryptophan catabolic process to kynurenine | IEA | biological_process |
| GO:0019442 | Tryptophan catabolic process to acetyl-CoA | IBA IEA | biological_process |
| GO:0019825 | Oxygen binding | IEA | molecular_function |
| GO:0020037 | Heme binding | IBA IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3139741385 | 0.6309806542 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3457547284 |
| GSE13712_SHEAR | Up | 0.0752456388 |
| GSE13712_STATIC | Down | -0.1618004132 |
| GSE19018 | Down | -0.1376540430 |
| GSE19899_A1 | Up | 0.1825703120 |
| GSE19899_A2 | Down | -0.3968763269 |
| PubMed_21979375_A1 | Up | 0.1727766861 |
| PubMed_21979375_A2 | Up | 0.3101718118 |
| GSE35957 | Up | 0.0697218496 |
| GSE36640 | Down | -0.0425949905 |
| GSE54402 | Down | -0.0569305658 |
| GSE9593 | Up | 0.0262256120 |
| GSE43922 | Down | -0.1040563004 |
| GSE24585 | Down | -0.0238797631 |
| GSE37065 | Up | 0.0094882745 |
| GSE28863_A1 | Down | -0.1351378334 |
| GSE28863_A2 | Up | 0.8072747115 |
| GSE28863_A3 | Up | 0.1156300602 |
| GSE28863_A4 | Up | 0.0504311634 |
| GSE48662 | Down | -0.1532856997 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
