HCSGD entry for BUB1
1. General information
| Official gene symbol | BUB1 |
|---|---|
| Entrez ID | 699 |
| Gene full name | BUB1 mitotic checkpoint serine/threonine kinase |
| Other gene symbols | BUB1A BUB1L hBUB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000776 | Kinetochore | IDA IEA | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IDA | cellular_component |
| GO:0000780 | Condensed nuclear chromosome, centromeric region | IEA | cellular_component |
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007059 | Chromosome segregation | IEA | biological_process |
| GO:0007063 | Regulation of sister chromatid cohesion | IDA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007093 | Mitotic cell cycle checkpoint | TAS | biological_process |
| GO:0007094 | Mitotic spindle assembly checkpoint | TAS | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016772 | Transferase activity, transferring phosphorus-containing groups | IEA | molecular_function |
| GO:0051983 | Regulation of chromosome segregation | IMP | biological_process |
| GO:0071173 | Spindle assembly checkpoint | IDA IMP | biological_process |
| GO:0071174 | Mitotic spindle checkpoint | IEA | biological_process |
| GO:2001244 | Positive regulation of intrinsic apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9597307245 | 0.0000602143 | 0.9999902473 | 0.0129909836 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3842960677 |
| GSE13712_SHEAR | Down | -0.0643312356 |
| GSE13712_STATIC | Down | -0.2833701895 |
| GSE19018 | Up | 0.1098643080 |
| GSE19899_A1 | Down | -0.3676832947 |
| GSE19899_A2 | Down | -1.7901606090 |
| PubMed_21979375_A1 | Down | -2.6998708657 |
| PubMed_21979375_A2 | Down | -2.0988865365 |
| GSE35957 | Down | -1.5363030230 |
| GSE36640 | Down | -3.7380375561 |
| GSE54402 | Down | -0.8718671827 |
| GSE9593 | Down | -0.6866888863 |
| GSE43922 | Down | -3.1478988551 |
| GSE24585 | Down | -0.1016047371 |
| GSE37065 | Down | -1.0258100597 |
| GSE28863_A1 | Down | -0.4733133026 |
| GSE28863_A2 | Up | 1.5318944169 |
| GSE28863_A3 | Down | -0.7229992692 |
| GSE28863_A4 | Up | 0.1462309308 |
| GSE48662 | Down | -2.0611824018 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-450a-1-3p | MIMAT0022700 | MIRT007183 | qRT-PCR//Western blot | Functional MTI | 23110129 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042691 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045266 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048279 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17968325 | These genes belong to very different biochemical families: csn2 (component of the Cop9 signalosome), aldose reductase (a metabolic enzyme) and brf1 (subunit of the RNA polymerase II complex), S-adenosyl homocysteine hydrolase and Bub1 |
| 17643075 | Bub1: escapades in a cellular world |
| 17643075 | The Bub1 kinase is a key spindle checkpoint regulatory protein |
| 17643075 | Bub1 also plays more pleiotropic roles |
| 17643075 | Thus, Bub1 is required for assembly of a functional inner centromere, sister chromatid cohesion via targeting of the Shugoshin protein, and metaphase congression |
| 17643075 | Evidence based on Bub1 mutations in colorectal cancers suggests it might be a driving force in tumorigenesis via generation of chromosomal instability (CIN) and aneuploidy |
| 17643075 | Recently we reported a surveillance mechanism linking loss of Bub1 to activation of the p53 pathway, specifically premature cell senescence in normal human fibroblasts |
| 17643075 | Interestingly, SV40 large T antigen (LT) targets Bub1 and this is correlated with oncogenic transformation and compromise of the spindle checkpoint |
| 17643075 | Future studies on Bub1 combining genetic approaches with analysis of LT perturbations are likely to yield further insight |
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