HCSGD entry for BTK
1. General information
| Official gene symbol | BTK |
|---|---|
| Entrez ID | 695 |
| Gene full name | Bruton agammaglobulinemia tyrosine kinase |
| Other gene symbols | AGMX1 AT ATK BPK IMD1 PSCTK1 XLA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000302 | Response to reactive oxygen species | IEA | biological_process |
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002250 | Adaptive immune response | TAS | biological_process |
| GO:0002553 | Histamine secretion by mast cell | IEA | biological_process |
| GO:0002721 | Regulation of B cell cytokine production | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002902 | Regulation of B cell apoptotic process | TAS | biological_process |
| GO:0004713 | Protein tyrosine kinase activity | EXP IEA TAS | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA TAS | molecular_function |
| GO:0005547 | Phosphatidylinositol-3,4,5-trisphosphate binding | IDA | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling | IEA | biological_process |
| GO:0007498 | Mesoderm development | TAS | biological_process |
| GO:0010033 | Response to organic substance | IEA | biological_process |
| GO:0019722 | Calcium-mediated signaling | TAS | biological_process |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
| GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA TAS | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
| GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
| GO:0042113 | B cell activation | TAS | biological_process |
| GO:0042629 | Mast cell granule | IEA | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045121 | Membrane raft | IDA | cellular_component |
| GO:0045579 | Positive regulation of B cell differentiation | TAS | biological_process |
| GO:0046777 | Protein autophosphorylation | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048469 | Cell maturation | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0050853 | B cell receptor signaling pathway | TAS | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | TAS | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8011996505 | 0.5450823145 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0293371057 |
| GSE13712_SHEAR | Down | -0.1553346830 |
| GSE13712_STATIC | Down | -0.0156128180 |
| GSE19018 | Down | -0.0801813436 |
| GSE19899_A1 | Down | -0.0958672282 |
| GSE19899_A2 | Up | 0.1682054919 |
| PubMed_21979375_A1 | Up | 0.0425149398 |
| PubMed_21979375_A2 | Down | -0.0760731705 |
| GSE35957 | Down | -0.0212973266 |
| GSE36640 | Up | 0.0372176316 |
| GSE54402 | Down | -0.0145963025 |
| GSE9593 | Up | 0.1032596903 |
| GSE43922 | Up | 0.0124774908 |
| GSE24585 | Up | 0.5430339751 |
| GSE37065 | Down | -0.0253265105 |
| GSE28863_A1 | Down | -0.2718937723 |
| GSE28863_A2 | Down | -0.2916512516 |
| GSE28863_A3 | Up | 0.1640970861 |
| GSE28863_A4 | Up | 0.0889854816 |
| GSE48662 | Down | -0.0175636986 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Inositol 1,3,4,5-Tetrakisphosphate | DB01863 | EXPT01943 | DB03265 |
| XL418 | DB05204 | - |
| Ibrutinib | DB09053 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-346 | MIMAT0000773 | MIRT001128 | Luciferase reporter assay//qRT-PCR//Northern blot//Western blot | Functional MTI | 19342689 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
