HCSGD entry for GCFC2
1. General information
| Official gene symbol | GCFC2 |
|---|---|
| Entrez ID | 6936 |
| Gene full name | GC-rich sequence DNA-binding factor 2 |
| Other gene symbols | C2orf3 DNABF GCF TCF9 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7026522776 | 0.0565088257 | 0.9999902473 | 0.4466431402 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1396501472 |
| GSE13712_SHEAR | Up | 0.1272688783 |
| GSE13712_STATIC | Up | 0.5352571343 |
| GSE19018 | Down | -0.3200462289 |
| GSE19899_A1 | Down | -0.0003036439 |
| GSE19899_A2 | Up | 0.2342239469 |
| PubMed_21979375_A1 | Up | 0.8885793624 |
| PubMed_21979375_A2 | Up | 0.2674942422 |
| GSE35957 | Down | -0.2343399491 |
| GSE36640 | Down | -0.3545300396 |
| GSE54402 | Down | -0.1286091352 |
| GSE9593 | Down | -0.3530629228 |
| GSE43922 | Down | -0.1543798983 |
| GSE24585 | Down | -0.8367877988 |
| GSE37065 | Down | -0.0110703936 |
| GSE28863_A1 | Up | 0.0559022943 |
| GSE28863_A2 | Up | 0.2408520537 |
| GSE28863_A3 | Down | -0.5466553939 |
| GSE28863_A4 | Down | -0.3326727349 |
| GSE48662 | Down | -0.2358700631 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002735 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020556 | Reporter assay;Other | Non-Functional MTI | 20584899 |
| hsa-miR-10a-3p | MIMAT0004555 | MIRT038676 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25826898 | Senescence marker (p16INK4a) and disc degeneration markers [A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS 5), Aggrecan, and Sry-related HMG box transcription factor 9 (Sox-9)] were determined in the NP specimens with immunohistochemistry and Western blot |
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