HCSGD entry for TCF3

1. General information

Official gene symbolTCF3
Entrez ID6929
Gene full nametranscription factor 3
Other gene symbolsE2A E47 ITF1 TCF-3 VDIR bHLHb21
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000788Nuclear nucleosomeIEAcellular_component
GO:0001779Natural killer cell differentiationIEAbiological_process
GO:0002326B cell lineage commitmentIDA NASbiological_process
GO:0003677DNA bindingIDA NASmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA NASmolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIDA IEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006351Transcription, DNA-templatedIDAbiological_process
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0030183B cell differentiationNASbiological_process
GO:0030890Positive regulation of B cell proliferationIMPbiological_process
GO:0031435Mitogen-activated protein kinase kinase kinase bindingIPImolecular_function
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0033152Immunoglobulin V(D)J recombinationIDA IEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042692Muscle cell differentiationTASbiological_process
GO:0042803Protein homodimerization activityIDA IEAmolecular_function
GO:0043234Protein complexIDAcellular_component
GO:0043425BHLH transcription factor bindingIPImolecular_function
GO:0043565Sequence-specific DNA bindingIDA IEAmolecular_function
GO:0043966Histone H3 acetylationIEAbiological_process
GO:0043967Histone H4 acetylationIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045666Positive regulation of neuron differentiationISSbiological_process
GO:0045787Positive regulation of cell cycleIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEA ISSbiological_process
GO:0046982Protein heterodimerization activityIDA IEA IPI NASmolecular_function
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0048468Cell developmentIEAbiological_process
GO:0048541Peyer's patch developmentIEAbiological_process
GO:0050821Protein stabilizationIEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0051149Positive regulation of muscle cell differentiationTASbiological_process
GO:0070491Repressing transcription factor bindingIPImolecular_function
GO:0070644Vitamin D response element bindingIDAmolecular_function
GO:0070888E-box bindingIDA ISSmolecular_function
GO:2000045Regulation of G1/S transition of mitotic cell cycleIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90358305160.31918416090.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0607900385
GSE13712_SHEARUp0.0668574523
GSE13712_STATICDown-0.0544575463
GSE19018Down-0.1189910880
GSE19899_A1Down-0.0179878466
GSE19899_A2Up0.1024638583
PubMed_21979375_A1Up0.3721984527
PubMed_21979375_A2Down-0.1885273717
GSE35957Down-0.3983702114
GSE36640Down-0.8018265232
GSE54402Up0.3017734217
GSE9593Down-0.1977974940
GSE43922Up0.0671411395
GSE24585Down-0.2061710688
GSE37065Down-0.3320441714
GSE28863_A1Down-0.0009750258
GSE28863_A2Up0.0280069820
GSE28863_A3Up0.0866161606
GSE28863_A4Up0.0569794800
GSE48662Up0.1000967585

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-17-5pMIMAT0000070MIRT007321Luciferase reporter assayFunctional MTI23492770
hsa-miR-124-3pMIMAT0000422MIRT023195MicroarrayFunctional MTI (Weak)18668037
hsa-miR-615-3pMIMAT0003283MIRT040470CLASHFunctional MTI (Weak)23622248
hsa-miR-342-3pMIMAT0000753MIRT043732CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044472CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26208142The proliferative peak in experimental rat nephritis coincided with a peak in E2A expression in the glomeruli
26208142This inhibitory effect was partially reversed by the knockdown of E2A
26208142We also demonstrated that E2A and p21 expression at the peak of proliferation was followed by significant induction of FLASH in mesangial areas in rat proliferative glomerulonephritis
26208142These results suggest that the functional interaction of E2A and FLASH play an important role in cell proliferation and cellular senescence via regulation of p21 expression in experimental glomerulonephritis
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