HCSGD entry for TAZ
1. General information
| Official gene symbol | TAZ |
|---|---|
| Entrez ID | 6901 |
| Gene full name | tafazzin |
| Other gene symbols | BTHS CMD3A EFE EFE2 G4.5 LVNCX Taz1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005739 | Mitochondrion | IC IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006936 | Muscle contraction | IMP | biological_process |
| GO:0007507 | Heart development | IMP | biological_process |
| GO:0007519 | Skeletal muscle tissue development | IMP | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016746 | Transferase activity, transferring acyl groups | IEA | molecular_function |
| GO:0030097 | Hemopoiesis | IMP | biological_process |
| GO:0032049 | Cardiolipin biosynthetic process | IMP | biological_process |
| GO:0032981 | Mitochondrial respiratory chain complex I assembly | IMP | biological_process |
| GO:0035965 | Cardiolipin acyl-chain remodeling | TAS | biological_process |
| GO:0042407 | Cristae formation | IMP | biological_process |
| GO:0042775 | Mitochondrial ATP synthesis coupled electron transport | IDA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity | IDA | molecular_function |
| GO:0048738 | Cardiac muscle tissue development | IMP | biological_process |
| GO:0060048 | Cardiac muscle contraction | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9121579879 | 0.3944263212 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0624420416 |
| GSE13712_SHEAR | Up | 0.0110776708 |
| GSE13712_STATIC | Down | -0.2714543113 |
| GSE19018 | Up | 0.0853143021 |
| GSE19899_A1 | Down | -0.1293935838 |
| GSE19899_A2 | Up | 0.0356926923 |
| PubMed_21979375_A1 | Down | -0.1827306129 |
| PubMed_21979375_A2 | Down | -0.1098945162 |
| GSE35957 | Down | -0.0324692859 |
| GSE36640 | Up | 0.0340925680 |
| GSE54402 | Up | 0.0456880437 |
| GSE9593 | Down | -0.1613390578 |
| GSE43922 | Up | 0.0552081794 |
| GSE24585 | Down | -0.2026746709 |
| GSE37065 | Down | -0.1217429665 |
| GSE28863_A1 | Up | 0.0987556447 |
| GSE28863_A2 | Up | 0.0148947702 |
| GSE28863_A3 | Up | 0.0327029802 |
| GSE28863_A4 | Down | -0.0496320127 |
| GSE48662 | Up | 0.0254134549 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017100 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029020 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039496 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051742 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27358050 | LATS-YAP/TAZ controls lineage specification by regulating TGFbeta signaling and Hnf4alpha expression during liver development |
| 27358050 | Here we report that the Hippo pathway controls liver cell lineage specification and proliferation separately from Notch signalling, using mice and primary hepatoblasts with liver-specific knockout of Lats1 and Lats2 kinase, the direct upstream regulators of YAP and TAZ |
| 27358050 | During and after liver development, the activation of YAP/TAZ induced by loss of Lats1/2 forces hepatoblasts or hepatocytes to commit to the biliary epithelial cell (BEC) lineage |
| 27358050 | Notably, oncogenic YAP/TAZ activation in hepatocytes induces massive p53-dependent cell senescence/death |
| 27358050 | Together, our results reveal that YAP/TAZ activity levels govern liver cell differentiation and proliferation in a context-dependent manner |
| 22068052 | In addition to acting as a transcriptional cofactor for p53, ASPP1 has been shown to function in the cytoplasm to regulate the nuclear localization and activity of YAP/TAZ |
| 17606438 | RESULTS: TBI reduced the pool of BM mesenchymal stem/progenitor cells, and altered osteoblast differentiation ability of BM MSC evidenced by changes in TAZ expression |
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