HCSGD entry for TAT
1. General information
| Official gene symbol | TAT |
|---|---|
| Entrez ID | 6898 |
| Gene full name | tyrosine aminotransferase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004838 | L-tyrosine:2-oxoglutarate aminotransferase activity | IDA NAS TAS | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006103 | 2-oxoglutarate metabolic process | IDA | biological_process |
| GO:0006536 | Glutamate metabolic process | IDA | biological_process |
| GO:0006559 | L-phenylalanine catabolic process | IEA TAS | biological_process |
| GO:0006572 | Tyrosine catabolic process | IDA | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0009058 | Biosynthetic process | IEA | biological_process |
| GO:0016597 | Amino acid binding | IEA | molecular_function |
| GO:0030170 | Pyridoxal phosphate binding | IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046689 | Response to mercury ion | IEA | biological_process |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0080130 | L-phenylalanine:2-oxoglutarate aminotransferase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7956760951 | 0.8318332472 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0033571140 |
| GSE13712_SHEAR | Down | -0.0701766006 |
| GSE13712_STATIC | Down | -0.1599289064 |
| GSE19018 | Down | -0.0600567608 |
| GSE19899_A1 | Up | 0.1117828852 |
| GSE19899_A2 | Down | -0.0857633713 |
| PubMed_21979375_A1 | Up | 0.0965159868 |
| PubMed_21979375_A2 | Down | -0.0736549836 |
| GSE35957 | Up | 0.2785833100 |
| GSE36640 | Down | -0.0042146532 |
| GSE54402 | Up | 0.0363057927 |
| GSE9593 | Up | 0.0289442299 |
| GSE43922 | Up | 0.0109876204 |
| GSE24585 | Up | 0.0271384755 |
| GSE37065 | Up | 0.0099408980 |
| GSE28863_A1 | Down | -0.0671516854 |
| GSE28863_A2 | Down | -0.1101193572 |
| GSE28863_A3 | Up | 0.1699123072 |
| GSE28863_A4 | Up | 0.0489017768 |
| GSE48662 | Up | 0.2553256138 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023561 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 6137440 | Properties of purified tyrosine aminotransferase from adult and senescent rat liver |
| 6137440 | Induced tyrosine aminotransferase from adult and old rat liver was purified and its properties were studied |
| 6137440 | Tyrosine aminotransferase provides another argument against the 'error theory' of cellular aging |
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