HCSGD entry for TAP2

1. General information

Official gene symbolTAP2
Entrez ID6891
Gene full nametransporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Other gene symbolsABC18 ABCB3 APT2 D6S217E PSF-2 PSF2 RING11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001916Positive regulation of T cell mediated cytotoxicityIBAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0002481Antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependentIBAbiological_process
GO:0002485Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependentIBAbiological_process
GO:0002489Antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependentIBA IMPbiological_process
GO:0002591Positive regulation of antigen processing and presentation of peptide antigen via MHC class IIBAbiological_process
GO:0005215Transporter activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005743Mitochondrial inner membraneIRDcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005886Plasma membraneIBAcellular_component
GO:0006200ATP catabolic processIBA IMPbiological_process
GO:0006857Oligopeptide transportIBAbiological_process
GO:0008152Metabolic processIBA IMPbiological_process
GO:0015197Peptide transporter activityIGImolecular_function
GO:0015421Oligopeptide-transporting ATPase activityIBAmolecular_function
GO:0015433Peptide antigen-transporting ATPase activityIMPmolecular_function
GO:0015833Peptide transportIBAbiological_process
GO:0016021Integral component of membraneIDAcellular_component
GO:0019060Intracellular transport of viral protein in host cellIMPbiological_process
GO:0019885Antigen processing and presentation of endogenous peptide antigen via MHC class IIDA IMPbiological_process
GO:0030176Integral component of endoplasmic reticulum membraneIDAcellular_component
GO:0035672Oligopeptide transmembrane transportIBAbiological_process
GO:0042288MHC class I protein bindingIBAmolecular_function
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042605Peptide antigen bindingIBAmolecular_function
GO:0042825TAP complexIBA IDAcellular_component
GO:0046967Cytosol to ER transportIMPbiological_process
GO:0046968Peptide antigen transportIDA IMPbiological_process
GO:0046978TAP1 bindingIBA IPImolecular_function
GO:0046979TAP2 bindingIBAmolecular_function
GO:0046980Tapasin bindingIBA ISSmolecular_function
GO:0055085Transmembrane transportIBAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02755851980.88157439310.38505214851.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1222320611
GSE13712_SHEARUp0.4540897781
GSE13712_STATICUp0.8294161371
GSE19018Up0.1081961971
GSE19899_A1Up0.1714787942
GSE19899_A2Up0.4968334506
PubMed_21979375_A1Up0.1780670950
PubMed_21979375_A2Up0.6972689369
GSE35957Down-0.1461113193
GSE36640Up1.7514157619
GSE54402Up0.2118844305
GSE9593Up0.2017961593
GSE43922Up0.0384323204
GSE24585Down-0.6575133879
GSE37065Up0.4968191445
GSE28863_A1Up0.0033343170
GSE28863_A2Up0.3301050009
GSE28863_A3Down-0.2565073397
GSE28863_A4Down-0.0975012157
GSE48662Down-0.1376706320

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.