HCSGD entry for TAF9

1. General information

Official gene symbolTAF9
Entrez ID6880
Gene full nameTAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
Other gene symbolsAK6 CGI-137 CINAP CIP MGC:1603 MGC:3647 MGC:5067 TAF2G TAFII31 TAFII32 TAFIID32 hCINAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000125PCAF complexIDAcellular_component
GO:0002039P53 bindingIPImolecular_function
GO:0003677DNA bindingIDA IEAmolecular_function
GO:0003713Transcription coactivator activityIDA IMPmolecular_function
GO:0004402Histone acetyltransferase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005669Transcription factor TFIID complexIDAcellular_component
GO:0006352DNA-templated transcription, initiationIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterTASbiological_process
GO:0006974Cellular response to DNA damage stimulusICbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0030307Positive regulation of cell growthIMPbiological_process
GO:0030914STAGA complexIDAcellular_component
GO:0032435Negative regulation of proteasomal ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0033276Transcription factor TFTC complexIDAcellular_component
GO:0033613Activating transcription factor bindingIPImolecular_function
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043966Histone H3 acetylationIDAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0050821Protein stabilizationIDAbiological_process
GO:0060760Positive regulation of response to cytokine stimulusIMPbiological_process
GO:0070555Response to interleukin-1IMPbiological_process
GO:0070742C2H2 zinc finger domain bindingIPImolecular_function
GO:0070761Pre-snoRNP complexIDAcellular_component
GO:0071339MLL1 complexIDAcellular_component
GO:1902166Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98822305760.21216330310.99999024730.8890861805

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.1945388323
GSE28863_A2Up0.1381060853
GSE28863_A3Down-0.4239348361
GSE28863_A4Down-0.0355889481
GSE48662Down-0.1225105693

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-421MIMAT0003339MIRT016116SequencingFunctional MTI (Weak)20371350
hsa-miR-26b-5pMIMAT0000083MIRT029623MicroarrayFunctional MTI (Weak)19088304
hsa-miR-16-5pMIMAT0000069MIRT031755ProteomicsFunctional MTI (Weak)18668040
hsa-let-7b-5pMIMAT0000063MIRT032332ProteomicsFunctional MTI (Weak)18668040
hsa-miR-505-3pMIMAT0002876MIRT040985CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23645206ZNF313 ubiquitinates p21(WAF1) and also destabilizes p27(KIP1) and p57(KIP2), three members of the CDK-interacting protein (CIP)/kinase inhibitor protein (KIP) family of cyclin-dependent kinase inhibitors, whereas it does not affect the stability of the inhibitor of CDK (INK4) family members, such as p16(INK4A) and p15(INK4B)
17599058Cell-cycle inhibitors of the Cip/Kip and INK4 families are involved in cellular senescence and tumor suppression
16936260Cellular senescence of biliary epithelial cells with p16INK4a and p21WAF1/Cip expression in damaged small bile ducts may be critical for progressive bile duct loss in primary biliary cirrhosis
15685690Biliary epithelial cells in small bile ducts in primary biliary cirrhosis, especially those in patients presenting with chronic non-suppurative cholangitis, frequently expressed senescence-associated beta-galactosidase, and senescence-associated p16(INK4) and p21(WAF1/CIP)
8706801Fourteen genes, including 3 cyclin-dependent kinase (CDK) inhibitors (p16INK4, p21SDI/CIP/WAF and p27KIP), 5 cyclins, 4 CDKs, Cdi-1, and PCNA were tested in four primary fibroblast strains
8706801These results corroborate and extend previous observations demonstrating elevated expression of specific cell cycle genes in higher passage cells and suggest that overexpression of the CDK-inhibitors p16INK4 and p21SDI/CIP/WAF, but not p27KIP, may contribute to lower proliferative activity of senescing primary fibroblasts
7616677In addition, the protein levels of CDK2 and cyclin E are also extremely low, with an increased level of the p53-dependent p21 Cip 1 protein which inhibits the kinase activity of cyclins/CDKs by forming complexes
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