HCSGD entry for T

1. General information

Official gene symbolT
Entrez ID6862
Gene full nameT, brachyury homolog (mouse)
Other gene symbolsTFT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000785ChromatinIEAcellular_component
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEA ISSmolecular_function
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIDAmolecular_function
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIEAmolecular_function
GO:0001085RNA polymerase II transcription factor bindingIEA ISSmolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingIPImolecular_function
GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptionIEA ISSmolecular_function
GO:0001570VasculogenesisIEAbiological_process
GO:0001756SomitogenesisIEAbiological_process
GO:0001839Neural plate morphogenesisIEAbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0003007Heart morphogenesisIDAbiological_process
GO:0003257Positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationIDA IEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA NASmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007341Penetration of zona pellucidaIEAbiological_process
GO:0007498Mesoderm developmentTASbiological_process
GO:0007509Mesoderm migration involved in gastrulationIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008595Anterior/posterior axis specification, embryoTASbiological_process
GO:0014028Notochord formationIEAbiological_process
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0036342Post-anal tail morphogenesisIEAbiological_process
GO:0048706Embryonic skeletal system developmentIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIEAbiological_process
GO:0060349Bone morphogenesisIEAbiological_process
GO:0060395SMAD protein signal transductionIEAbiological_process
GO:0061371Determination of heart left/right asymmetryIEAbiological_process
GO:0090009Primitive streak formationNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42654372170.87133984650.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1562970408
GSE13712_SHEARUp0.0572301330
GSE13712_STATICDown-0.0183611219
GSE19018Down-0.0443200226
GSE19899_A1Down-0.0100234620
GSE19899_A2Down-0.0321815360
PubMed_21979375_A1Down-0.0994984635
PubMed_21979375_A2Up0.1678652013
GSE35957Up0.3718432330
GSE36640Up0.0386639438
GSE54402Up0.0771222877
GSE9593Down-0.1312263375
GSE43922Up0.0306545797
GSE24585Up0.2595462289
GSE37065Up0.0188608430
GSE28863_A1Down-0.0480630685
GSE28863_A2Up0.1492778746
GSE28863_A3Up0.1860733965
GSE28863_A4Up0.1384612539
GSE48662Up0.0992461457

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.