HCSGD entry for SYT1
1. General information
| Official gene symbol | SYT1 |
|---|---|
| Entrez ID | 6857 |
| Gene full name | synaptotagmin I |
| Other gene symbols | P65 SVP65 SYT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001786 | Phosphatidylserine binding | IEA | molecular_function |
| GO:0005215 | Transporter activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005513 | Detection of calcium ion | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005543 | Phospholipid binding | TAS | molecular_function |
| GO:0005544 | Calcium-dependent phospholipid binding | IEA | molecular_function |
| GO:0005545 | 1-phosphatidylinositol binding | TAS | molecular_function |
| GO:0005546 | Phosphatidylinositol-4,5-bisphosphate binding | IEA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007269 | Neurotransmitter secretion | TAS | biological_process |
| GO:0008021 | Synaptic vesicle | IEA TAS | cellular_component |
| GO:0008022 | Protein C-terminus binding | IEA | molecular_function |
| GO:0014047 | Glutamate secretion | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016079 | Synaptic vesicle exocytosis | IEA | biological_process |
| GO:0017075 | Syntaxin-1 binding | IEA TAS | molecular_function |
| GO:0017157 | Regulation of exocytosis | TAS | biological_process |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0030276 | Clathrin binding | IEA | molecular_function |
| GO:0030666 | Endocytic vesicle membrane | TAS | cellular_component |
| GO:0030672 | Synaptic vesicle membrane | IEA | cellular_component |
| GO:0031045 | Dense core granule | IEA | cellular_component |
| GO:0031340 | Positive regulation of vesicle fusion | IEA | biological_process |
| GO:0042584 | Chromaffin granule membrane | IEA | cellular_component |
| GO:0042734 | Presynaptic membrane | IEA | cellular_component |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0045956 | Positive regulation of calcium ion-dependent exocytosis | IEA | biological_process |
| GO:0048278 | Vesicle docking | IEA | biological_process |
| GO:0048306 | Calcium-dependent protein binding | IEA | molecular_function |
| GO:0050750 | Low-density lipoprotein particle receptor binding | IDA | molecular_function |
| GO:0051260 | Protein homooligomerization | TAS | biological_process |
| GO:0051592 | Response to calcium ion | IEA | biological_process |
| GO:0060076 | Excitatory synapse | IEA | cellular_component |
| GO:0060201 | Clathrin-sculpted acetylcholine transport vesicle membrane | TAS | cellular_component |
| GO:0060203 | Clathrin-sculpted glutamate transport vesicle membrane | TAS | cellular_component |
| GO:0061202 | Clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane | TAS | cellular_component |
| GO:0070083 | Clathrin-sculpted monoamine transport vesicle membrane | TAS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3478425478 | 0.0201562973 | 0.9999902473 | 0.2750905132 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2118833702 |
| GSE13712_SHEAR | Up | 0.6485371979 |
| GSE13712_STATIC | Up | 0.2828114473 |
| GSE19018 | Down | -0.1555811185 |
| GSE19899_A1 | Down | -0.0579696889 |
| GSE19899_A2 | Down | -1.7329592544 |
| PubMed_21979375_A1 | Down | -1.9568495504 |
| PubMed_21979375_A2 | Down | -2.7083620892 |
| GSE35957 | Down | -0.5278983069 |
| GSE36640 | Up | 0.3660474642 |
| GSE54402 | Down | -1.0689948077 |
| GSE9593 | Down | -0.0495449311 |
| GSE43922 | Down | -0.5753816758 |
| GSE24585 | Up | 0.2674997701 |
| GSE37065 | Up | 0.3642072408 |
| GSE28863_A1 | Down | -0.5068193982 |
| GSE28863_A2 | Up | 0.2031854238 |
| GSE28863_A3 | Down | -0.0785038318 |
| GSE28863_A4 | Up | 0.2359599201 |
| GSE48662 | Down | -0.0510534559 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT006304 | Luciferase reporter assay//Western blot | Functional MTI | 22160687 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017696 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
