HCSGD entry for VAMP2

1. General information

Official gene symbolVAMP2
Entrez ID6844
Gene full namevesicle-associated membrane protein 2 (synaptobrevin 2)
Other gene symbolsSYB2 VAMP-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005484SNAP receptor activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006892Post-Golgi vesicle-mediated transportTASbiological_process
GO:0006906Vesicle fusionIBAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007269Neurotransmitter secretionTASbiological_process
GO:0008021Synaptic vesicleIBAcellular_component
GO:0014047Glutamate secretionTASbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016192Vesicle-mediated transportIEAbiological_process
GO:0017157Regulation of exocytosisIBAbiological_process
GO:0019905Syntaxin bindingIBAmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0030136Clathrin-coated vesicleIDAcellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0030667Secretory granule membraneTAScellular_component
GO:0030672Synaptic vesicle membraneIEAcellular_component
GO:0031201SNARE complexIDAcellular_component
GO:0043005Neuron projectionIEAcellular_component
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0060203Clathrin-sculpted glutamate transport vesicle membraneTAScellular_component
GO:0061202Clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneTAScellular_component
GO:0070083Clathrin-sculpted monoamine transport vesicle membraneTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02041442950.46153530640.34356023021.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1346296249
GSE13712_SHEARDown-0.0641140610
GSE13712_STATICDown-0.1609626462
GSE19018Up0.7538144891
GSE19899_A1Down-0.2691687005
GSE19899_A2Up0.8065222005
PubMed_21979375_A1Down-0.1423984167
PubMed_21979375_A2Up0.4035887484
GSE35957Up0.1750321931
GSE36640Up2.1029912399
GSE54402Down-0.0172463415
GSE9593Up0.1758780872
GSE43922Down-0.4435434537
GSE24585Up0.5401934167
GSE37065Up0.1079235184
GSE28863_A1Down-0.2415709425
GSE28863_A2Down-0.3321447624
GSE28863_A3Up0.2736447307
GSE28863_A4Down-0.1546060193
GSE48662Up0.9659161475

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Botulinum Toxin Type BDB00042 BTD00070 | BIOD00070

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT001758Luciferase reporter assayFunctional MTI14697198
hsa-let-7e-5pMIMAT0000066MIRT051508CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.