HCSGD entry for SUPV3L1
1. General information
| Official gene symbol | SUPV3L1 |
|---|---|
| Entrez ID | 6832 |
| Gene full name | suppressor of var1, 3-like 1 (S. cerevisiae) |
| Other gene symbols | SUV3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000958 | Mitochondrial mRNA catabolic process | IMP | biological_process |
| GO:0000962 | Positive regulation of mitochondrial RNA catabolic process | IDA IMP | biological_process |
| GO:0000965 | Mitochondrial RNA 3'-end processing | IMP | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IMP | molecular_function |
| GO:0003678 | DNA helicase activity | IMP | molecular_function |
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0003725 | Double-stranded RNA binding | IDA | molecular_function |
| GO:0004004 | ATP-dependent RNA helicase activity | IDA | molecular_function |
| GO:0004386 | Helicase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006310 | DNA recombination | IMP | biological_process |
| GO:0006401 | RNA catabolic process | IMP | biological_process |
| GO:0030307 | Positive regulation of cell growth | IMP | biological_process |
| GO:0032508 | DNA duplex unwinding | IMP | biological_process |
| GO:0034458 | 3'-5' RNA helicase activity | IDA | molecular_function |
| GO:0035945 | Mitochondrial ncRNA surveillance | IMP | biological_process |
| GO:0035946 | Mitochondrial mRNA surveillance | IMP | biological_process |
| GO:0042645 | Mitochondrial nucleoid | IDA | cellular_component |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0045025 | Mitochondrial degradosome | IDA | cellular_component |
| GO:0070584 | Mitochondrion morphogenesis | IMP | biological_process |
| GO:0070827 | Chromatin maintenance | IMP | biological_process |
| GO:2000827 | Mitochondrial RNA surveillance | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0123671365 | 0.7284276281 | 0.2779807003 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4983610286 |
| GSE13712_SHEAR | Up | 0.1379900394 |
| GSE13712_STATIC | Up | 0.2687843215 |
| GSE19018 | Down | -0.1330923694 |
| GSE19899_A1 | Up | 0.3147557383 |
| GSE19899_A2 | Up | 0.9538217113 |
| PubMed_21979375_A1 | Up | 1.8374293018 |
| PubMed_21979375_A2 | Up | 1.4656644351 |
| GSE35957 | Down | -0.3064742279 |
| GSE36640 | Up | 0.0927314191 |
| GSE54402 | Up | 0.7175648466 |
| GSE9593 | Down | -0.0682860619 |
| GSE43922 | Up | 0.6635375759 |
| GSE24585 | Down | -0.2335467956 |
| GSE37065 | Up | 0.0480902430 |
| GSE28863_A1 | Down | -0.1724699085 |
| GSE28863_A2 | Up | 0.2539653107 |
| GSE28863_A3 | Down | -0.7518246508 |
| GSE28863_A4 | Up | 0.0945471443 |
| GSE48662 | Down | -0.1943562368 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027436 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-320a | MIMAT0000510 | MIRT044646 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046174 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT046569 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18678873 | Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells |
| 18678873 | Yeast lacking the Suv3 component of the mtEXO form petits and undergo a toxic accumulation of omega intron RNAs |
| 18678873 | Mammalian mitochondria resemble their prokaryotic origins by harboring a polyadenylation-dependent RNA degradation mechanism, but whether SUV3 participates in regulating RNA turnover in mammalian mitochondria is unclear |
| 18678873 | This suggests that SUV3 may serve in part as a component of an RNA degradosome, resembling its yeast ancestor |
| 18678873 | Thus, our results suggest that SUV3 is essential for maintaining proper mitochondrial function, likely through a conserved role in mitochondrial RNA regulation |
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