HCSGD entry for SUPT5H

1. General information

Official gene symbolSUPT5H
Entrez ID6829
Gene full namesuppressor of Ty 5 homolog (S. cerevisiae)
Other gene symbolsSPT5 SPT5H Tat-CT1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006338Chromatin remodelingNASbiological_process
GO:0006354DNA-templated transcription, elongationIDAbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterIDA TASbiological_process
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0007049Cell cycleNASbiological_process
GO:0010033Response to organic substanceTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016239Positive regulation of macroautophagyIMPbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0032044DSIF complexIDAcellular_component
GO:0032785Negative regulation of DNA-templated transcription, elongationIDAbiological_process
GO:0032786Positive regulation of DNA-templated transcription, elongationIDAbiological_process
GO:0039692Single stranded viral RNA replication via double stranded DNA intermediateNASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0050434Positive regulation of viral transcriptionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00463065990.99673489610.17897738621.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4631965990
GSE13712_SHEARUp0.0405740382
GSE13712_STATICUp0.0840909190
GSE19018Up0.1903304177
GSE19899_A1Up0.4165177478
GSE19899_A2Up0.7566247855
PubMed_21979375_A1Up1.3466927812
PubMed_21979375_A2Up2.4727349157
GSE35957Up0.3113537997
GSE36640Up0.3201247724
GSE54402Up0.4619288293
GSE9593Up0.0860320535
GSE43922Up0.3676377594
GSE24585Up0.1561433939
GSE37065Down-0.0611404985
GSE28863_A1Up0.0911887025
GSE28863_A2Up0.1523373303
GSE28863_A3Up0.4743159688
GSE28863_A4Up0.1150702157
GSE48662Up0.1186900097

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020754ProteomicsFunctional MTI (Weak)18668040
hsa-miR-34a-5pMIMAT0000255MIRT025307ProteomicsFunctional MTI (Weak)21566225
hsa-miR-26b-5pMIMAT0000083MIRT029450MicroarrayFunctional MTI (Weak)19088304
hsa-miR-1229-3pMIMAT0005584MIRT036363CLASHFunctional MTI (Weak)23622248
hsa-miR-935MIMAT0004978MIRT036670CLASHFunctional MTI (Weak)23622248
hsa-miR-93-3pMIMAT0004509MIRT038889CLASHFunctional MTI (Weak)23622248
hsa-miR-92b-3pMIMAT0003218MIRT040704CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042043CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042864CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045555CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049464CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051148CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26418880In the present study, suppressor of Ty homolog-5 (SPT5), a protein encoded by the SUPT5H gene, was identified as a novel tumor-specific hTERT promoter-binding protein and activator in colon cancer cells
26418880We verified the tumor-specific binding activity of SPT5 to the hTERT promoter in vitro and in vivo and detected high expression levels of SUPT5H in colorectal cancer cell lines and primary human colorectal cancer tissues
26418880SUPT5H was more highly expressed in colorectal cancer cases with distant metastasis than in cases without distant metastasis
26418880Inhibition of endogenous SUPT5H expression by SUPT5H gene-specific short hairpin RNAs effectively attenuated hTERT promoter-driven green fluorescent protein (GFP) expression, whereas no detectable effects on CMV promoter-driven GFP expression in the same cells were observed
26418880In addition, inhibition of SUPT5H expression not only effectively repressed telomerase activity, accelerated telomere shortening, and promoted cell senescence in colon cancer cells, but also suppressed cancer cell growth and migration
26418880Our results demonstrated that SPT5 contributes to the up-regulation of hTERT expression and tumor development, and SUPT5H may potentially be used as a novel tumor biomarker and/or cancer therapeutic target
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