HCSGD entry for STXBP1

1. General information

Official gene symbolSTXBP1
Entrez ID6812
Gene full namesyntaxin binding protein 1
Other gene symbolsMUNC18-1 NSEC1 P67 RBSEC1 UNC18
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000149SNARE bindingISSmolecular_function
GO:0002576Platelet degranulationIMPbiological_process
GO:0005737CytoplasmISScellular_component
GO:0005739MitochondrionISScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDA ISScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006904Vesicle docking involved in exocytosisIEAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007269Neurotransmitter secretionTASbiological_process
GO:0007274Neuromuscular synaptic transmissionIEAbiological_process
GO:0007412Axon target recognitionISSbiological_process
GO:0010807Regulation of synaptic vesicle primingISSbiological_process
GO:0014047Glutamate secretionTASbiological_process
GO:0015031Protein transportIEAbiological_process
GO:0016188Synaptic vesicle maturationISSbiological_process
GO:0017075Syntaxin-1 bindingISSmolecular_function
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0019905Syntaxin bindingIPImolecular_function
GO:0031091Platelet alpha granuleIDAcellular_component
GO:0032229Negative regulation of synaptic transmission, GABAergicISSbiological_process
GO:0042802Identical protein bindingISSmolecular_function
GO:0043234Protein complexISScellular_component
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045956Positive regulation of calcium ion-dependent exocytosisIEAbiological_process
GO:0047485Protein N-terminus bindingIEAmolecular_function
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0050821Protein stabilizationIEAbiological_process
GO:0060292Long term synaptic depressionIEAbiological_process
GO:0070527Platelet aggregationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00025264620.99809564610.04448366011.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1981666968
GSE13712_SHEARDown-0.4718020746
GSE13712_STATICDown-0.0547052979
GSE19018Up0.5621385527
GSE19899_A1Up1.0472005614
GSE19899_A2Up1.3948631652
PubMed_21979375_A1Up1.5887682039
PubMed_21979375_A2Up1.7220098119
GSE35957Up0.4056299995
GSE36640Up1.6491625360
GSE54402Up0.6565039511
GSE9593Up0.5759755556
GSE43922Up0.5735346960
GSE24585Up0.7212228985
GSE37065Up0.1006457323
GSE28863_A1Up0.5982062338
GSE28863_A2Up0.8720364611
GSE28863_A3Up0.4914721719
GSE28863_A4Up0.0055942237
GSE48662Up0.4572345611

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-378a-3pMIMAT0000732MIRT043952CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046505CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050254CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.