HCSGD entry for STX1A

1. General information

Official gene symbolSTX1A
Entrez ID6804
Gene full namesyntaxin 1A (brain)
Other gene symbolsHPC-1 P35-1 STX1 SYN1A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000149SNARE bindingIEAmolecular_function
GO:0001948Glycoprotein bindingIEAmolecular_function
GO:0001956Positive regulation of neurotransmitter secretionIEAbiological_process
GO:0005484SNAP receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006836Neurotransmitter transportIEAbiological_process
GO:0006886Intracellular protein transportIEAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007269Neurotransmitter secretionTASbiological_process
GO:0009629Response to gravityIEAbiological_process
GO:0014047Glutamate secretionTASbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016081Synaptic vesicle docking involved in exocytosisIEAbiological_process
GO:0016192Vesicle-mediated transportIEAbiological_process
GO:0017156Calcium ion-dependent exocytosisIEAbiological_process
GO:0019855Calcium channel inhibitor activityIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0030141Secretory granuleIEAcellular_component
GO:0030672Synaptic vesicle membraneIEAcellular_component
GO:0030674Protein binding, bridgingIEAmolecular_function
GO:0031201SNARE complexIDAcellular_component
GO:0032028Myosin head/neck bindingIEAmolecular_function
GO:0042641ActomyosinIEAcellular_component
GO:0043005Neuron projectionIDAcellular_component
GO:0043008ATP-dependent protein bindingIEAmolecular_function
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045921Positive regulation of exocytosisIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0047485Protein N-terminus bindingIEAmolecular_function
GO:0048306Calcium-dependent protein bindingIEAmolecular_function
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0070032Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complexIEAcellular_component
GO:0070033Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complexIEAcellular_component
GO:0070044Synaptobrevin 2-SNAP-25-syntaxin-1a complexIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00767188560.96126753540.22806951631.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4441526743
GSE13712_SHEARUp0.7450847370
GSE13712_STATICUp0.4303605751
GSE19018Down-0.2976763814
GSE19899_A1Up0.4630534723
GSE19899_A2Up0.6199872253
PubMed_21979375_A1Up1.9158398814
PubMed_21979375_A2Up1.1843627083
GSE35957Down-0.3273886204
GSE36640Up0.2280065334
GSE54402Up0.5313971510
GSE9593Up0.0686561078
GSE43922Up0.5401445324
GSE24585Down-0.2063727343
GSE37065Up0.2410708354
GSE28863_A1Down-0.1352288775
GSE28863_A2Up0.3737743384
GSE28863_A3Up0.1415647558
GSE28863_A4Down-0.0037598380
GSE48662Down-0.1814157633

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT006305Luciferase reporter assay//Western blotFunctional MTI22160687
hsa-miR-335-5pMIMAT0000765MIRT018783MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT030051MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24253049These changes correlated with 1) increased expression of miR-29 and its regulator p53, 2) reduced expression of syntaxin-1a, a direct target of miR-29, and 3) altered expression of genes related to cellular senescence
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