HCSGD entry for NEK4
1. General information
| Official gene symbol | NEK4 |
|---|---|
| Entrez ID | 6787 |
| Gene full name | NIMA-related kinase 4 |
| Other gene symbols | NRK2 STK2 pp12301 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IEA TAS | molecular_function |
| GO:0004702 | Receptor signaling protein serine/threonine kinase activity | IBA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007165 | Signal transduction | IBA | biological_process |
| GO:0016772 | Transferase activity, transferring phosphorus-containing groups | IEA | molecular_function |
| GO:0023014 | Signal transduction by phosphorylation | IBA | biological_process |
| GO:0035556 | Intracellular signal transduction | IBA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1198753961 | 0.9125484404 | 0.7085267849 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1692819884 |
| GSE13712_SHEAR | Up | 0.3209594256 |
| GSE13712_STATIC | Up | 0.1797101240 |
| GSE19018 | Down | -0.0493120614 |
| GSE19899_A1 | Up | 0.1133656903 |
| GSE19899_A2 | Up | 0.2316074761 |
| PubMed_21979375_A1 | Up | 0.0770560756 |
| PubMed_21979375_A2 | Up | 0.0008154284 |
| GSE35957 | Down | -0.3308765475 |
| GSE36640 | Down | -0.3604983243 |
| GSE54402 | Up | 0.2097743209 |
| GSE9593 | Down | -0.0327806809 |
| GSE43922 | Up | 0.0979954023 |
| GSE24585 | Up | 0.0440704625 |
| GSE37065 | Down | -0.0863018608 |
| GSE28863_A1 | Up | 0.9792690076 |
| GSE28863_A2 | Up | 0.3830273632 |
| GSE28863_A3 | Up | 0.1928413299 |
| GSE28863_A4 | Down | -0.0313822185 |
| GSE48662 | Up | 0.0232088381 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-197-3p | MIMAT0000227 | MIRT004215 | Microarray | Functional MTI (Weak) | 16822819 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
