HCSGD entry for STAT5A

1. General information

Official gene symbolSTAT5A
Entrez ID6776
Gene full namesignal transducer and activator of transcription 5A
Other gene symbolsMGF STAT5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000255Allantoin metabolic processISSbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0001553LuteinizationIEAbiological_process
GO:0001779Natural killer cell differentiationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006101Citrate metabolic processISSbiological_process
GO:00061032-oxoglutarate metabolic processISSbiological_process
GO:0006105Succinate metabolic processISSbiological_process
GO:0006107Oxaloacetate metabolic processISSbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006549Isoleucine metabolic processISSbiological_process
GO:0006573Valine metabolic processISSbiological_process
GO:0006600Creatine metabolic processISSbiological_process
GO:0006631Fatty acid metabolic processISSbiological_process
GO:0007259JAK-STAT cascadeIEA TASbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007595LactationIEAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0019218Regulation of steroid metabolic processIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIEAbiological_process
GO:0019530Taurine metabolic processISSbiological_process
GO:0019915Lipid storageIEAbiological_process
GO:0030155Regulation of cell adhesionIEAbiological_process
GO:0030856Regulation of epithelial cell differentiationIEAbiological_process
GO:0032825Positive regulation of natural killer cell differentiationIEAbiological_process
GO:0033026Negative regulation of mast cell apoptotic processIEAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0038161Prolactin signaling pathwayISSbiological_process
GO:0040014Regulation of multicellular organism growthISSbiological_process
GO:0040018Positive regulation of multicellular organism growthIEAbiological_process
GO:0042104Positive regulation of activated T cell proliferationIEAbiological_process
GO:0043029T cell homeostasisIEAbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0045086Positive regulation of interleukin-2 biosynthetic processIEAbiological_process
GO:0045579Positive regulation of B cell differentiationIEAbiological_process
GO:0045588Positive regulation of gamma-delta T cell differentiationIEAbiological_process
GO:0045647Negative regulation of erythrocyte differentiationIEAbiological_process
GO:0045931Positive regulation of mitotic cell cycleIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0045954Positive regulation of natural killer cell mediated cytotoxicityIEAbiological_process
GO:0046449Creatinine metabolic processISSbiological_process
GO:0046543Development of secondary female sexual characteristicsIEAbiological_process
GO:0046544Development of secondary male sexual characteristicsIEAbiological_process
GO:0048541Peyer's patch developmentIEAbiological_process
GO:0050729Positive regulation of inflammatory responseIEAbiological_process
GO:0060376Positive regulation of mast cell differentiationIEAbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTASbiological_process
GO:0060740Prostate gland epithelium morphogenesisIEAbiological_process
GO:0060742Epithelial cell differentiation involved in prostate gland developmentIEAbiological_process
GO:0061180Mammary gland epithelium developmentIEAbiological_process
GO:0070668Positive regulation of mast cell proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40380967290.18976669200.99999024730.8444708925

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0136871118
GSE13712_SHEARDown-0.2726168774
GSE13712_STATICDown-0.1564876362
GSE19018Up0.1151667088
GSE19899_A1Up0.1712554966
GSE19899_A2Down-0.0344484164
PubMed_21979375_A1Down-0.6658286907
PubMed_21979375_A2Up0.1007152536
GSE35957Up0.0616436167
GSE36640Down-0.8851220602
GSE54402Down-1.0794753440
GSE9593Down-0.0225915774
GSE43922Down-0.0812365400
GSE24585Up0.2093465055
GSE37065Up0.0706766373
GSE28863_A1Up0.7672401393
GSE28863_A2Up0.3488636502
GSE28863_A3Up0.1993397151
GSE28863_A4Down-0.0749680316
GSE48662Down-0.0628032640

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-222-3pMIMAT0000279MIRT000018qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20489169
hsa-miR-124-3pMIMAT0000422MIRT023082MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-222-3pMIMAT00002791hsa-miR-222{Western blot}{overexpression by miRNA precursor transfection}20489169
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22926520However, upon ectopic expression of BCR-ABL p210 in non-myeloid cells, co-transfected STAT5A is phosphorylated on Y694 and localized in the nucleus arguing for an additional factor mediating cytoplasmic retention in CML cells
22926520Expression of the SFK v-Src, Hck or Lyn together with STAT5A results in phosphorylation on Y694 and cytoplasmic retention
22926520Cytoplasmic retention depends on the kinase activity of SFK and is mediated through the interaction of the SH2 domain of STAT5A with the SFK
22926520Interestingly, nuclear accumulation of STAT5A as a result of activation by FLT3-ITD, an oncogene found in acute myeloid leukemia, cannot be prevented by coexpression of SFK
22532803Epigenome-wide association scans (EWAS) identified age-related phenotype DMRs (ap-DMRs) associated with LDL (STAT5A), lung function (WT1), and maternal longevity (ARL4A, TBX20)
17913706We found that constitutively active STAT5A (ca-STAT5A) can induce a p53- and Rb-dependent cellular senescence response
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