HCSGD entry for STAT1

1. General information

Official gene symbolSTAT1
Entrez ID6772
Gene full namesignal transducer and activator of transcription 1, 91kDa
Other gene symbolsCANDF7 ISGF-3 STAT91
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0001937Negative regulation of endothelial cell proliferationIMPbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationISSbiological_process
GO:0003340Negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisISSbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003690Double-stranded DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005164Tumor necrosis factor receptor bindingIPImolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006915Apoptotic processISSbiological_process
GO:0007259JAK-STAT cascadeIDAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008015Blood circulationIEA ISSbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016525Negative regulation of angiogenesisIMPbiological_process
GO:0019221Cytokine-mediated signaling pathwayIEA TASbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0030424AxonIEA ISScellular_component
GO:0030425DendriteIEA ISScellular_component
GO:0031663Lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0031730CCR5 chemokine receptor bindingIEAmolecular_function
GO:0032869Cellular response to insulin stimulusIEAbiological_process
GO:0033209Tumor necrosis factor-mediated signaling pathwayIDAbiological_process
GO:0034097Response to cytokineISSbiological_process
GO:0034240Negative regulation of macrophage fusionIEAbiological_process
GO:0035458Cellular response to interferon-betaIMPbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043124Negative regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0043330Response to exogenous dsRNAIEAbiological_process
GO:0043434Response to peptide hormoneISSbiological_process
GO:0043542Endothelial cell migrationIMPbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIEA ISSbiological_process
GO:0051591Response to cAMPIEA ISSbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayIDA ISS TASbiological_process
GO:0060334Regulation of interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayISS TASbiological_process
GO:0060338Regulation of type I interferon-mediated signaling pathwayTASbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTASbiological_process
GO:0061326Renal tubule developmentIMPbiological_process
GO:0072136Metanephric mesenchymal cell proliferation involved in metanephros developmentISSbiological_process
GO:0072162Metanephric mesenchymal cell differentiationISSbiological_process
GO:0072308Negative regulation of metanephric nephron tubule epithelial cell differentiationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00515437860.72263821660.18764647301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8502293647
GSE13712_SHEARUp1.8206170814
GSE13712_STATICUp0.8289403169
GSE19018Down-0.3546891361
GSE19899_A1Up0.0513833466
GSE19899_A2Up0.3193174575
PubMed_21979375_A1Down-0.5029386902
PubMed_21979375_A2Up0.3537646902
GSE35957Down-0.3600374856
GSE36640Up1.2090110647
GSE54402Down-0.2543806203
GSE9593Up1.2887224866
GSE43922Down-0.0032896545
GSE24585Up1.1791411047
GSE37065Up0.3173239636
GSE28863_A1Up0.0787187876
GSE28863_A2Up0.9715202716
GSE28863_A3Down-0.3052757526
GSE28863_A4Down-0.3298234330
GSE48662Up0.1044566464

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-145-5pMIMAT0000437MIRT000626qRT-PCR//Luciferase reporter assay//Western blot//MicroarrayFunctional MTI20098684
hsa-miR-146a-5pMIMAT0000449MIRT021229MicroarrayFunctional MTI (Weak)20110513
hsa-miR-34a-5pMIMAT0000255MIRT025278ProteomicsFunctional MTI (Weak)21566225
hsa-miR-615-3pMIMAT0003283MIRT040456CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-146a-5pMIMAT00004491hsa-miR-146a{Western blot}{overexpression by miRNA precursor transfection}19333922
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27188231In addition, we observed a decrease in osteoclastogenesis and bone resorption accompanied by upregulation of STAT1 expression in osteoclast lineage cells
23984931STAT1 and STAT3 activity were increased in tBHP-induced cells
22864395Significantly, higher IFNbeta and chemokine gene transcripts have been observed, together with increased STAT1 and decreased STAT3 and NF-kappaB signaling activities
22217266Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin II induced premature senescence
22217266The signal transducer and activator of transcription 1 (STAT1) is a latent transcription factor involved in a variety of signal transduction pathways, including cell proliferation, apoptosis, and differentiation, but whether it could regulate HMC senescence still remains to be explored
22217266STAT1 knockdown using RNA interference significantly inhibited the progression of HMC senescence and decreased the elevated expression of p53 and p21(Cip1)
22217266Our results indicate that STAT1 is implicated in the mediation of Ang II-induced HMC senescence through p53/ p21(Cip1) pathway, and that losartan could attenuate HMC senescence by regulating STAT1
22193460The STAT1 and STAT3 activity and the expression of p53 and p21(Cip1) were increased after Angiotensin II and H(2)O(2) treatment
21472252Compared to the AngII-induced group, in the cells treated with losartan and AG490, the characteristics of cell senescence were ameliorated, and the expression of STAT1, STAT3, pSTAT1 and pSTAT3 was decreased
19802007Here, we show that genotoxic drugs capable of inducing premature senescence in normal and cancer cells, such as 5-bromo-2'-deoxyuridine (BrdU), distamycin A (DMA), aphidicolin and hydroxyurea, persistently activate Janus kinase-signal transducer and activator of transcription (JAK/STAT) signaling and expression of interferon-stimulated genes (ISGs), such as MX1, OAS, ISG15, STAT1, PML, IRF1 and IRF7, in several human cancer cell lines
17266044The lines overexpressed EEF1A2, SMARA3 and STAT1 and underexpressed other oncogenes, tumor suppressors and extracellular matrix/adhesion genes
16426144Stat1 expression is not sufficient to regulate the interferon signaling pathway in cellular immortalization
16426144In this study we focused on a key regulator of that pathway, the signal transducer and transcription activator 1 (Stat1) gene
16426144Although Stat1 is downregulated after cellular immortalization and upregulated in immortal MDAH041 cells after 5-aza-2'-deoxycytidine (5-aza-dC) treatment, we detected no methylation of the Stat1 promoter region in these cells before or after immortalization
16426144To analyze the function of Stat1 in immortalization, we expressed Stat1 in immortal MDAH041 cells by stable infection, expecting to induce IFN-regulated genes or cellular senescence or both
16426144However, the overexpression of Stat1 alone was not sufficient to repress the proliferation rate of immortal MDAH041 cells or induce senescence in immortal MDAH041 cells
16426144We concluded that factor(s) additional to Stat1 (whether IFN dependent or not) are required for the immortalization of LFS fibroblasts
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