HCSGD entry for STAR

1. General information

Official gene symbolSTAR
Entrez ID6770
Gene full namesteroidogenic acute regulatory protein
Other gene symbolsSTARD1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005758Mitochondrial intermembrane spaceIEA TAScellular_component
GO:0005829CytosolIEAcellular_component
GO:0006694Steroid biosynthetic processIEA TASbiological_process
GO:0006699Bile acid biosynthetic processIEAbiological_process
GO:0006700C21-steroid hormone biosynthetic processTASbiological_process
GO:0006701Progesterone biosynthetic processIEAbiological_process
GO:0006703Estrogen biosynthetic processIEAbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0008211Glucocorticoid metabolic processIEAbiological_process
GO:0008584Male gonad developmentIEAbiological_process
GO:0009635Response to herbicideIEAbiological_process
GO:0010212Response to ionizing radiationIEAbiological_process
GO:0010288Response to lead ionIEAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0014823Response to activityIEAbiological_process
GO:0015485Cholesterol bindingIEAmolecular_function
GO:0016101Diterpenoid metabolic processIEAbiological_process
GO:0017127Cholesterol transporter activityIEAmolecular_function
GO:0017143Insecticide metabolic processIEAbiological_process
GO:0018879Biphenyl metabolic processIEAbiological_process
GO:0018894Dibenzo-p-dioxin metabolic processIEAbiological_process
GO:0018958Phenol-containing compound metabolic processIEAbiological_process
GO:0018963Phthalate metabolic processIEAbiological_process
GO:0030061Mitochondrial cristaIEAcellular_component
GO:0032367Intracellular cholesterol transportIEAbiological_process
GO:0032869Cellular response to insulin stimulusIEAbiological_process
GO:0035094Response to nicotineIEAbiological_process
GO:0035457Cellular response to interferon-alphaIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042747Circadian sleep/wake cycle, REM sleepIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0044321Response to leptinIEAbiological_process
GO:0044344Cellular response to fibroblast growth factor stimulusIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0048168Regulation of neuronal synaptic plasticityIEAbiological_process
GO:0050756Fractalkine metabolic processIEAbiological_process
GO:0050769Positive regulation of neurogenesisIEAbiological_process
GO:0050810Regulation of steroid biosynthetic processIEAbiological_process
GO:0051412Response to corticosteroneIEAbiological_process
GO:0060992Response to fungicideIEAbiological_process
GO:0061370Testosterone biosynthetic processIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071236Cellular response to antibioticIEAbiological_process
GO:0071276Cellular response to cadmium ionIEAbiological_process
GO:0071312Cellular response to alkaloidIEAbiological_process
GO:0071320Cellular response to cAMPIEAbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
GO:0071346Cellular response to interferon-gammaIEAbiological_process
GO:0071372Cellular response to follicle-stimulating hormone stimulusIEAbiological_process
GO:0071373Cellular response to luteinizing hormone stimulusIEAbiological_process
GO:0071378Cellular response to growth hormone stimulusIEAbiological_process
GO:0071549Cellular response to dexamethasone stimulusIEAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEAbiological_process
GO:0071872Cellular response to epinephrine stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75919398960.56358924050.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1617921133
GSE13712_SHEARDown-0.0965718475
GSE13712_STATICDown-0.1307006282
GSE19018Down-0.0954621461
GSE19899_A1Up0.1517556542
GSE19899_A2Down-0.0033255874
PubMed_21979375_A1Down-0.2096149750
PubMed_21979375_A2Down-0.1938081536
GSE35957Up0.0206704932
GSE36640Up0.0166266555
GSE54402Up0.1227082665
GSE9593Up0.0378150814
GSE43922Up0.0263650682
GSE24585Down-0.0839772369
GSE37065Up0.0324172833
GSE28863_A1Down-0.1311485206
GSE28863_A2Down-0.1440670534
GSE28863_A3Up0.2654395898
GSE28863_A4Down-0.0036119234
GSE48662Down-0.0348014013

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15611563Previous studies have shown that the capacity of Leydig cells from aged (21-24-month-old) Brown Norway rats to produce testosterone is reduced from young (4-month-old) levels, and that this is correlated with reductions in steroidogenic acute regulatory protein (StAR), peripheral benzodiazapine receptor (PBR), and the levels and activities of the steroidogenic enzymes
11191081Leydig cell aging: steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme
11191081To better understand the mechanism by which aging Leydig cells lose steroidogenic function, we examined the effect of aging on steroidogenic acute regulatory protein (StAR), an important Leydig cell cholesterol transfer protein, and on P450scc
10993816Steroidogenic acute regulatory protein and mRNA levels are reduced in old Leydig cells, suggesting that there may be deficits in the transport of cholesterol to the inner mitochondrial membrane of aged cells
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