HCSGD entry for ST14

1. General information

Official gene symbolST14
Entrez ID6768
Gene full namesuppression of tumorigenicity 14 (colon carcinoma)
Other gene symbolsHAI MT-SP1 MTSP1 PRSS14 SNC19 TADG15 TMPRSS14
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004252Serine-type endopeptidase activityIEAmolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006508ProteolysisIDAbiological_process
GO:0008236Serine-type peptidase activityIDAmolecular_function
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0019897Extrinsic component of plasma membraneIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15309371600.95614550740.77996389421.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0134368045
GSE13712_SHEARUp0.0622577321
GSE13712_STATICDown-0.1073791594
GSE19018Up0.1653407710
GSE19899_A1Up0.0702192468
GSE19899_A2Up0.2141922485
PubMed_21979375_A1Up0.0275694540
PubMed_21979375_A2Up0.0775480688
GSE35957Up0.0771641193
GSE36640Down-0.0244142576
GSE54402Up0.0739278422
GSE9593Up0.1098957948
GSE43922Up0.0253175703
GSE24585Up0.3252120821
GSE37065Down-0.0233163183
GSE28863_A1Down-0.1695080003
GSE28863_A2Up0.0353918648
GSE28863_A3Up0.4721798987
GSE28863_A4Up0.0185044476
GSE48662Up1.3166352933

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

UrokinaseDB00013 BTD00030 | BIOD00030
BenzamidineDB03127 EXPT00669

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-27b-3pMIMAT0000419MIRT003388Luciferase reporter assay//Microarray//Northern blot//qRT-PCR//Western blotFunctional MTI19546220
hsa-miR-335-5pMIMAT0000765MIRT017020MicroarrayFunctional MTI (Weak)18185580
hsa-miR-615-3pMIMAT0003283MIRT039751CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-27b-3pMIMAT00004191hsa-miR-27b{Western blot}{overexpression by miRNA precursor transfection}19546220
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23722523A recombinant matriptase causes an increase in caspase-3 activity in a small-intestinal epithelial IEC-6 line cultured on fibronectin-coated plates
237225231 muM) caused an increased detachment of and increases in the activity of apoptotic effector caspase-3 in a rat small-intestinal epithelial IEC-6 line cultured on laminin-coated plates and proposed that at sites with its high level of expression, matriptase contributes to promoting shedding and/or detachment-induced death of epithelial cells through a mechanism mediating loss of cell-ECM adhesion
23722523In this study, we found that even without increasing cell detachment, a high concentration of r-MatCD causes an increase in caspase-3 activity in IEC-6 cells cultured on fibronectin-coated plates, suggesting that the recombinant matriptase can cause apoptosis by a mechanism unrelated to cell detachment
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