HCSGD entry for TRIM21

1. General information

Official gene symbolTRIM21
Entrez ID6737
Gene full nametripartite motif containing 21
Other gene symbolsRNF81 RO52 SSA SSA1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000209Protein polyubiquitinationIDAbiological_process
GO:0000932Cytoplasmic mRNA processing bodyIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006513Protein monoubiquitinationIDAbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0019005SCF ubiquitin ligase complexIDAcellular_component
GO:0030529Ribonucleoprotein complexTAScellular_component
GO:0031648Protein destabilizationIMPbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0032479Regulation of type I interferon productionTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045787Positive regulation of cell cycleIMPbiological_process
GO:0051865Protein autoubiquitinationIDAbiological_process
GO:0070206Protein trimerizationIDAbiological_process
GO:0090086Negative regulation of protein deubiquitinationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41834155240.02046958700.99999024730.2764167692

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0289988470
GSE13712_SHEARUp0.9438436221
GSE13712_STATICUp1.2820771612
GSE19018Down-0.5345876025
GSE19899_A1Down-0.3330516423
GSE19899_A2Down-0.6617783106
PubMed_21979375_A1Down-0.8292161532
PubMed_21979375_A2Down-0.7977055419
GSE35957Down-0.9227588668
GSE36640Down-0.6111785273
GSE54402Down-0.2127529355
GSE9593Down-0.1238179608
GSE43922Down-0.3317563284
GSE24585Up0.3120022287
GSE37065Up0.8348708027
GSE28863_A1Down-0.2744972809
GSE28863_A2Up0.3310737974
GSE28863_A3Down-0.8712242834
GSE28863_A4Up0.1441701921
GSE48662Up0.0524420733

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.