HCSGD entry for SRP54


1. General information

Official gene symbolSRP54
Entrez ID6729
Gene full namesignal recognition particle 54kDa
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003924GTPase activityIDA IEAmolecular_function
GO:0005525GTP bindingIDA IEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005786Signal recognition particle, endoplasmic reticulum targetingIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006184GTP catabolic processIDAbiological_process
GO:0006412TranslationTASbiological_process
GO:0006614SRP-dependent cotranslational protein targeting to membraneIC IEA TASbiological_process
GO:0006616SRP-dependent cotranslational protein targeting to membrane, translocationISSbiological_process
GO:0006617SRP-dependent cotranslational protein targeting to membrane, signal sequence recognitionISSbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:00083127S RNA bindingIDA IEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0016607Nuclear speckIEAcellular_component
GO:0019003GDP bindingIDAmolecular_function
GO:0030942Endoplasmic reticulum signal peptide bindingIDAmolecular_function
GO:0042493Response to drugIDAbiological_process
GO:0043021Ribonucleoprotein complex bindingIDAmolecular_function
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045047Protein targeting to ERIMPbiological_process
GO:0048500Signal recognition particleIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06900791000.88295313250.56237099971.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1935132548
GSE13712_SHEARUp0.1257422431
GSE13712_STATICUp0.0966438330
GSE19018Up0.4021881984
GSE19899_A1Up0.4728400315
GSE19899_A2Up0.1070098339
PubMed_21979375_A1Up0.3796734071
PubMed_21979375_A2Up0.1965775233
GSE35957Down-0.1960029384
GSE36640Up0.2125769444
GSE54402Up0.2950980489
GSE9593Down-0.3508668270
GSE43922Up0.2148067130
GSE24585Up0.2167681868
GSE37065Up0.3030681554
GSE28863_A1Down-0.1124629688
GSE28863_A2Up0.2759524170
GSE28863_A3Down-0.6902637510
GSE28863_A4Up0.2000099278
GSE48662Down-0.3749101827

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-423-5pMIMAT0004748MIRT038146CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.