HCSGD entry for SRM
1. General information
| Official gene symbol | SRM |
|---|---|
| Entrez ID | 6723 |
| Gene full name | spermidine synthase |
| Other gene symbols | PAPT SPDSY SPS1 SRML1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004766 | Spermidine synthase activity | IDA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006595 | Polyamine metabolic process | TAS | biological_process |
| GO:0008295 | Spermidine biosynthetic process | IDA IEA | biological_process |
| GO:0016740 | Transferase activity | IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1080115535 | 0.0744267847 | 0.6821991365 | 0.5141699213 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6796309588 |
| GSE13712_SHEAR | Up | 0.1730957779 |
| GSE13712_STATIC | Up | 0.1362131580 |
| GSE19018 | Down | -0.8198934365 |
| GSE19899_A1 | Down | -0.5632649085 |
| GSE19899_A2 | Down | -0.0656182504 |
| PubMed_21979375_A1 | Up | 2.1538011876 |
| PubMed_21979375_A2 | Up | 0.1030846687 |
| GSE35957 | Down | -0.6304171836 |
| GSE36640 | Down | -0.2567478951 |
| GSE54402 | Up | 0.5396528213 |
| GSE9593 | Down | -0.1412286308 |
| GSE43922 | Up | 0.1485468448 |
| GSE24585 | Down | -0.8366703122 |
| GSE37065 | Down | -0.5428338474 |
| GSE28863_A1 | Up | 0.1298350260 |
| GSE28863_A2 | Up | 0.4295141670 |
| GSE28863_A3 | Up | 0.2585084704 |
| GSE28863_A4 | Down | -0.1568751675 |
| GSE48662 | Down | -0.2985807718 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025815 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037588 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037815 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038148 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044635 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
