HCSGD entry for AKR1D1
1. General information
| Official gene symbol | AKR1D1 |
|---|---|
| Entrez ID | 6718 |
| Gene full name | aldo-keto reductase family 1, member D1 |
| Other gene symbols | 3o5bred CBAS2 SRD5B1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005496 | Steroid binding | TAS | molecular_function |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006699 | Bile acid biosynthetic process | IDA TAS | biological_process |
| GO:0006707 | Cholesterol catabolic process | IDA | biological_process |
| GO:0007586 | Digestion | IDA | biological_process |
| GO:0008206 | Bile acid metabolic process | TAS | biological_process |
| GO:0008207 | C21-steroid hormone metabolic process | IDA | biological_process |
| GO:0008209 | Androgen metabolic process | IDA | biological_process |
| GO:0030573 | Bile acid catabolic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047787 | Delta4-3-oxosteroid 5beta-reductase activity | IEA | molecular_function |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5804367577 | 0.6755938870 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3802991194 |
| GSE13712_SHEAR | Up | 0.1309854962 |
| GSE13712_STATIC | Down | -0.2694449351 |
| GSE19018 | Up | 0.1377851625 |
| GSE19899_A1 | Down | -0.1043491199 |
| GSE19899_A2 | Down | -0.1001682519 |
| PubMed_21979375_A1 | Up | 0.0572944086 |
| PubMed_21979375_A2 | Down | -0.0553419611 |
| GSE35957 | Up | 0.0045237832 |
| GSE36640 | Up | 0.0000106492 |
| GSE54402 | Up | 0.2348557259 |
| GSE9593 | Up | 0.0561355300 |
| GSE43922 | Up | 0.0111825773 |
| GSE24585 | Up | 0.1609435541 |
| GSE37065 | Down | -0.0953194379 |
| GSE28863_A1 | Down | -0.1670558818 |
| GSE28863_A2 | Up | 0.0557894986 |
| GSE28863_A3 | Up | 0.1143475894 |
| GSE28863_A4 | Up | 0.0165479848 |
| GSE48662 | Down | -0.0573592326 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Finasteride | DB01216 | APRD00632 | DB07774 |
| 5-beta-DIHYDROTESTOSTERONE | DB07447 | - |
| (5BETA)-PREGNANE-3,20-DIONE | DB07557 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT024083 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
