HCSGD entry for SRI

1. General information

Official gene symbolSRI
Entrez ID6717
Gene full namesorcin
Other gene symbolsCP-22 CP22 SCN V19
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001508Action potentialTASbiological_process
GO:0002020Protease bindingIPImolecular_function
GO:0005102Receptor bindingTASmolecular_function
GO:0005246Calcium channel regulator activityTASmolecular_function
GO:0005509Calcium ion bindingIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmTAScellular_component
GO:0005789Endoplasmic reticulum membraneIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006810TransportTASbiological_process
GO:0006816Calcium ion transportIEAbiological_process
GO:0006880Intracellular sequestering of iron ionTASbiological_process
GO:0006942Regulation of striated muscle contractionTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007507Heart developmentTASbiological_process
GO:0007517Muscle organ developmentTASbiological_process
GO:0008016Regulation of heart contractionTASbiological_process
GO:0010459Negative regulation of heart rateIMPbiological_process
GO:0010649Regulation of cell communication by electrical couplingTASbiological_process
GO:0010880Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumTASbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016529Sarcoplasmic reticulumTAScellular_component
GO:0030018Z discIDAcellular_component
GO:0030315T-tubuleTAScellular_component
GO:0033017Sarcoplasmic reticulum membraneIEAcellular_component
GO:0035774Positive regulation of insulin secretion involved in cellular response to glucose stimulusIEAbiological_process
GO:0042584Chromaffin granule membraneIDAcellular_component
GO:0042994Cytoplasmic sequestering of transcription factorIEAbiological_process
GO:0044325Ion channel bindingTASmolecular_function
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolIEAbiological_process
GO:0051924Regulation of calcium ion transportIMPbiological_process
GO:0060315Negative regulation of ryanodine-sensitive calcium-release channel activityIDAbiological_process
GO:0070491Repressing transcription factor bindingIEAmolecular_function
GO:0086004Regulation of cardiac muscle cell contractionIMPbiological_process
GO:1901077Regulation of relaxation of muscleIMPbiological_process
GO:1901841Regulation of high voltage-gated calcium channel activityIMPbiological_process
GO:1901844Regulation of cell communication by electrical coupling involved in cardiac conductionIMPbiological_process
GO:2000678Negative regulation of transcription regulatory region DNA bindingIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97704787810.01024575810.99999024730.2002068300

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1916574509
GSE13712_SHEARDown-0.5139081592
GSE13712_STATICDown-0.2586076318
GSE19018Down-0.1416060560
GSE19899_A1Down-0.8873796114
GSE19899_A2Down-0.7982892674
PubMed_21979375_A1Down-1.0260806125
PubMed_21979375_A2Down-1.1816128317
GSE35957Up0.0118718599
GSE36640Up0.4278290485
GSE54402Down-0.2377906040
GSE9593Up0.0216596075
GSE43922Down-0.1296365260
GSE24585Down-0.6981687430
GSE37065Down-0.2158049069
GSE28863_A1Up0.0627571931
GSE28863_A2Up0.3354902230
GSE28863_A3Down-0.4307475421
GSE28863_A4Down-0.1985438341
GSE48662Down-0.3219406297

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023807ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.